| アブストラクト | BACKGROUND: Diabetic nephropathy is a common complication of diabetes. We investigated the risk factors for diabetic nephropathy in individuals newly diagnosed with type 2 diabetes. METHODS: Data from the Japanese Diagnosis Procedure Combination in-patient database (April 2008 to December 2018) were analyzed. The endpoint was subsequent diabetic nephropathy diagnosis or as the time when estimated glomerular filtration rate become <60 ml/min/1.73 m(2). Candidate risk factors included age, Hemoglobin A1c, log-transformed triglyceride, total cholesterol, and high-density lipoprotein cholesterol levels, body mass index, and estimated glomerular filtration rate. Eligible individuals with type 2 diabetes without complications who had pre- and post-diagnosis Hemoglobin A1c and serum creatinine measurements, and a history of hypertension or cardiovascular disease pre-diagnosis. Those with pre-existing kidney diseases, nephropathy onset pre-diagnosis, estimated glomerular filtration rate <60 ml/min/1.73 m(2) on or before diabetes diagnosis, or age <20 years at diabetes diagnosis were excluded. A multivariate Cox proportional hazards model (p = 0.2 backward selection) was employed. RESULTS: Of 2,664 eligible individuals (1,775 men, 889 women), 325 men and 175 women developed diabetic nephropathy during follow-up. Cumulative incidence within 5 years was 29.0% in men and 32.5% in women. Age and estimated glomerular filtration rate in both sexes, and total cholesterol in men were significant. CONCLUSIONS: Age, estimated glomerular filtration rate, and lipid pose potential risks for diabetic nephropathy onset within 5 years of diabetes diagnosis in individuals with hypertension. Collectively, our findings highlight the importance of early monitoring and intervention in this high-risk. |
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| ジャーナル名 | Annals of clinical epidemiology |
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| Pubmed追加日 | 2025/7/23 |
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| 投稿者 | Ishigaki Suzuki, Tomoko; Saito Oba, Mari; Uemura, Kohei |
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| 組織名 | Department of Biostatistics and Information, Graduate School of Medicine, The;University of Tokyo, Tokyo, Japan.;Clinical Research & Education Promotion Division, National Center of Neurology;and Psychiatry, Tokyo, Japan.;Interfaculty Initiative in Information Studies, The University of Tokyo, Tokyo,;Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40697797/ |
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