| アブストラクト | BACKGROUND: Sodium-glucose co-transporter-2 inhibitors (SGLT2i) have been widely used in the management of type 2 diabetes, with proven cardiovascular and renal benefits. However, their use has been associated with a risk of diabetic ketoacidosis (DKA). AIM: This study aims to describe the characteristics of DKA cases associated with SGLT2i use in patients aged 65 and over, based on data from the French pharmacovigilance database. METHODS: A retrospective analysis was conducted on all cases of DKA reported with SGLT2i in patients aged 65 years and older. Cases were retrieved from 2020 onward; 55 were analyzed. Patient characteristics, drug exposure, adverse drug reaction (ADR) reports, hospitalization details, and precipitating factors were examined. RESULTS: Median patient age was 74.0 years (IQR: 69.0; 77.5), with a predominance of males (63.4 %). The median Charlson comorbidity index was 8.0 (IQR: 6.0; 10.0), and polypharmacy was common, with a median of nine drugs per patient. Infections (36.4 %), dehydration (20.0 %), and fasting (18.2 %) were the main precipitating factors. All cases required hospitalization, with 36.4 % admitted to an intensive care unit (ICU). Among ICU patients, 35.0 % required orotracheal intubation and/or vasopressor therapy. One case (1.8 %) resulted in death. Factors significantly associated with ICU admission included younger age (71.3 vs. 75.4 years, P = 0.009), lower pH at admission (P = 0.003), and infection as a precipitating factor (P = 0.007). CONCLUSION: This study highlights the clinical characteristics and risk factors of SGLT2i-associated DKA in older adults. Infections and severe acidosis were key predictors of ICU admission. The findings underscore the importance of careful patient selection and monitoring to mitigate DKA risk in older patients receiving SGLT2i therapy. |
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| 投稿者 | Bassas Letissier, Nathanael; Mirfendereski, Nassir; Laroche, Marie-Laure; Faillie, Jean-Luc; Paccalin, Marc; Saulnier, Pierre-Jean; Allouchery, Marion; Mosbah, Helena |
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| 組織名 | Department of Geriatrics, Poitiers University Hospital, Poitiers 86021, France.;Electronic address: nathanael.bassas@chu-poitiers.fr.;Universite de Poitiers, CHU de Poitiers, Pharmacologie clinique et Vigilances,;F-86000 Poitiers, France.;Pharmacovigilance and Pharmacoepidemiology Centre, Limoges University Hospital,;Limoges, France; VieSante Unit - UR 24134, Omega Health Institut, Limoges;University, Limoges, France.;Clinical Pharmacology and Vigilance, Montpellier University Hospital, Montpellier;34000, France.;Department of Geriatrics, Poitiers University Hospital, Poitiers 86021, France;;University of Poitiers, Poitiers, 86000, France.;Poitiers University, Poitiers University Hospital, INSERM, Centre d'Investigation;Clinique CIC1402, Poitiers, France.;Department of Endocrinology, Diabetology and Nutrition, Poitiers University;Hospital, INSERM, Centre d'Investigation Clinique CIC1402, Poitiers 86021,;France; University of Poitiers, Poitiers, 86000, France. |
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