| アブストラクト | BACKGROUND/OBJECTIVES: Acute pancreatitis (AP) is a major gastrointestinal disorder with an increasing global incidence. However, the impact of coronavirus disease 2019 (COVID-19) on AP remains unclear, particularly in Japan. This study aimed to investigate the association between AP and COVID-19, including the influence of comorbidities, using a Japanese nationwide administrative database. METHODS: We retrospectively analyzed patients with AP who were hospitalized between April 2020 and March 2023, registered in the Diagnosis Procedure Combination database. Patients were classified into COVID-19-negative and COVID-19-positive groups. Propensity score matching was performed to adjust for potential confounders in the analysis of factors associated with severe AP. RESULTS: Among 65,770 patients with AP, 548 (0.8 %) were COVID-19-positive, with COVID-19 recorded as a comorbidity at admission in 345 patients and as a secondary diagnosis during hospitalization in 203 patients. Compared with the COVID-19-negative group, the COVID-19-positive group had a higher proportion of severe AP (42.0 % vs. 30.2 %), intensive care unit admissions (4.6 % vs. 2.7 %), mechanical ventilation (5.5 % vs. 2.5 %), interventions for local complications (3.3 % vs. 1.8 %), and in-hospital mortality (5.0 % vs. 2.5 %). After propensity score matching, COVID-19 positivity and renal disease were associated with severe AP. When stratified by the timing of COVID-19 diagnosis, patients diagnosed during hospitalization were older, had longer hospital stays, and experienced higher in-hospital mortality compared with those without COVID-19 or those diagnosed at admission. CONCLUSIONS: Patients with concurrent COVID-19 infection, particularly those diagnosed during hospitalization, are at increased risk of severe AP and in-hospital mortality compared to those without COVID-19. |
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| ジャーナル名 | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
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| Pubmed追加日 | 2025/8/28 |
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| 投稿者 | Manaka, Tomoo; Tarasawa, Kunio; Takikawa, Tetsuya; Kikuta, Kazuhiro; Matsumoto, Ryotaro; Tanaka, Yu; Sano, Takanori; Hamada, Shin; Miura, Shin; Kume, Kiyoshi; Fujimori, Kenji; Fushimi, Kiyohide; Masamune, Atsushi |
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| 組織名 | Division of Gastroenterology, Tohoku University Graduate School of Medicine,;Sendai, Japan.;Department of Health Administration and Policy, Tohoku University Graduate School;of Medicine, Sendai, Japan.;Sendai, Japan. Electronic address: tetsuya.takikawa.c2@tohoku.ac.jp.;Department of Health Policy and Informatics, Institute of Science Tokyo, Tokyo,;Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40866153/ |
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