| アブストラクト | BACKGROUND: Cancer is one of the most common complications after kidney transplantation and an important cause of mortality. However, no large, nationally representative study has investigated cancer incidence post-kidney transplantation. This study aimed to determine the standardized incidence ratio (SIR) for cancer after kidney transplantation using the National Database of Health Insurance Claims (NDB). METHODS: We used NDB from April 2013 to March 2022; patients were included if they had been on dialysis for at least one year, were diagnosed with cancer related to post-kidney transplantation, and were prescribed immunosuppressant drugs in FY2014 or FY2015. We defined patients with cancer as those who were coded as ICD-10 for cancer in FY2016 or later. The number of patients and SIRs were tabulated according to the duration after kidney transplantation and cancer type. RESULTS: The total number of patients was 4484 (males: 2879; females: 1605). The SIRs of all cancers from the first to the seventh year after kidney transplantation were 232/291/235/248/257/187/149, respectively, showing a gradual downward trend over time. The predilection sites of cancer in both men and women were post-transplant lymphoproliferative disease, Kaposi sarcoma, and the kidney. CONCLUSION: This observational study, which followed over 100 million people, is the first large-scale research to track kidney transplant recipients for under 10 years. It incorporates an unprecedented sample size and uniquely identified short-term cancer risk trends following kidney transplantation. |
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| ジャーナル名 | Clinical and experimental nephrology |
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| Pubmed追加日 | 2025/8/27 |
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| 投稿者 | Kanno, Saho; Noda, Tatsuya; Myojin, Tomoya; Nishioka, Yuichi; Kubo, Shinichiro; Eriguchi, Masahiro; Samejima, Ken-Ichi; Tsuruya, Kazuhiko; Imamura, Tomoaki |
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| 組織名 | Department of Public Health, Health Management and Policy, Nara Medical;University, 840 Shijyo-Cho, Kashihara City, Nara, 634-8521, Japan.;noda@naramed-u.ac.jp.;Department of Community Health and Preventive Medicine, Hamamatsu University;School of Medicine, 1-20-1 Handayama, Chuo-Ku, Hamamatsu, Shizuoka, 431-3192,;Japan.;Department of Nephrology, Nara Medical University, 840 Shijo-Cho, Kashihara,;Nara, 634-8521, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40864337/ |
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