| アブストラクト | BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially fatal cutaneous adverse events of drug treatment. Evidence for SJS/TEN risk from current anticancer therapies in population-based studies is scarce. OBJECTIVE: The present study aims to characterize the profiles and risk factors of SJS/TEN related to contemporary anticancer regimens. METHODS: Reported odds ratios (ROR) were employed to identify anticancer drugs associated with SJS/TEN development using FAERS data from January 2004 to September 2024. Single factor, LASSO, and multivariable logistic regression analysis were performed to explore the risk factors of SJS/TEN related to anticancer therapies. Weibull shape parameter analysis was applied to the onset time of reported SJS/TEN. RESULTS: A total of 3471 unique SJS/TEN events were identified for 159 anticancer drug pairs, of which 31 drugs were identified as significantly disproportionate. Targeted therapies accounted for 35.93% of pairs, chemotherapies for 35.52%, and immunotherapies for 21.52%. The median onset time of SJS/TEN with anticancer therapies was 17 days. Moreover, multivariable logistic regression showed that age exceeding 65, female gender, and 10 anticancer drugs were significant risk factors for anticancer therapy-related SJS/TEN. CONCLUSIONS: This study provides real-world evidence regarding the burden of SJS/TEN associated with anticancer therapies. Addressing this knowledge gap will facilitate the optimization of clinical management for SJS/TEN. Further research to establish causality and inform clinical decision-making related to anticancer therapy-associated SJS/TEN is urgently needed. |
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| ジャーナル名 | Frontiers in immunology |
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| Pubmed追加日 | 2025/9/12 |
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| 投稿者 | Liu, Wensheng; Song, Xue; Du, Qiong; Liu, Jiyong |
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| 組織名 | Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, China.;Department of Oncology, Shanghai Medical College, Fudan University,;Shanghai, China.;Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of;Medicine, Shanghai, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40936888/ |
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