| アブストラクト | This study utilizes the U.S. Food and Drug Administration's (FDA) Adverse Event Reporting System (FAERS) database to analyze adverse reactions related to inner ear signs and symptoms potentially associated with antidepressant use. By examining FAERS data from the first quarter of 2004 to the fourth quarter of 2023, we observed higher reporting rates of tinnitus, vertigo, labyrinthitis, positional vertigo, and vestibular ataxia in association with antidepressants. Through de-duplication, standardization, and classification of the data, we identified adverse reaction reports linked to inner ear signs and symptoms and conducted an in-depth analysis of eight commonly used antidepressants. The results suggest a significant association between antidepressants- such as duloxetine, paroxetine, bupropion, venlafaxine, sertraline, desvenlafaxine, escitalopram, and citalopram- and inner ear signs and symptoms. These symptoms may severely impact patients' quality of life and daily functioning, highlighting the need for clinicians to closely monitor patients for inner ear signs and symptoms when prescribing these medications. |
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| 組織名 | Lishui Second People's Hospital, Lishui, 323000, China.;Department of Vascular Surgery, Eastern Hepatobiliary Surgery Hospital, Second;Military Medical University, Navy Medical University, Shanghai, 200438, China.;Peking University Medical Zibo Hospital Affiliated to Qilu College of Medicine,;Zibo, 255000, China.;Department of Obstetrics and Gynecology, Center for Reproductive Medicine, the;Fourth Affiliated Hospital of School of Medicine, and International School of;Medicine, International Institutes of Medicine, Zhejiang University, Yiwu,;322000, China.;Department of Gastroenterology, The Central Hospital of Enshi Tujia and Miao;Autonomous Prefecture, Enshi, 445000, China. dyz2020@whu.edu.cn.;Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.;cgp818@whu.edu.cn.;Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence,;Guangdong-Hong Kong-Macao, Southern Medical University, Guangzhou, 510515, China.;Department of Neurobiology, School of Basic Medical Sciences, Southern Medical;University, Guangzhou, 510515, China. cgp818@whu.edu.cn.;Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060,;China. cgp818@whu.edu.cn. |
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