| アブストラクト | BACKGROUND/AIMS: Guidelines recommend that steroid treatment for ulcerative colitis (UC) is tapered or withdrawn within 3 months of initiation, and thiopurine treatment or advanced therapy is administered for steroid-dependent UC. This study aimed to clarify real-world treatment patterns and outcomes in patients with steroid-dependent UC in Japan. METHODS: A retrospective analysis of JMDC (Japan Medical Data Center) claims data was conducted to identify patients with a new UC diagnosis between June 2010 and September 2019. Index dates were the UC treatment start date (initiation of any UC treatment), steroid dependence/resistance confirmation date (identification of steroid-dependent UC), and treatment intensification date (initiation of thiopurine treatment/advanced therapy). RESULTS: Of 5,602 patients with newly diagnosed UC, 986 (17.6%) initiated steroids within 12 months (85.4% [842/986] received 5-aminosalicylic acid at the UC treatment start date). Of these 986 patients, 429 (43.5%) were classified as steroid-dependent (steroid dependence/resistance confirmation date). Of these 429 patients, 128 (29.8%) initiated thiopurine treatment and 75 (17.5%) initiated advanced therapy (treatment intensification date); 226 (52.7%) continued with steroids only. Across these groups, 3-6% discontinued steroids within 3 months of initiation. Hospitalization due to UC in the 12 months after the treatment intensification date occurred in 24.2% (31/128) and 18.7% (14/75) of patients who initiated thiopurine and advanced therapy, respectively. CONCLUSIONS: Over half of patients with steroid-dependent UC continued steroid treatment only. Steroid discontinuation within 3 months of initiation was low, irrespective of whether thiopurines or advanced therapy were initiated. Management of patients with steroid-dependent UC in Japan requires further treatment optimization toward guideline adherence. |
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| ジャーナル名 | Intestinal research |
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| Pubmed追加日 | 2025/11/13 |
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| 投稿者 | Saruta, Masayuki; Sugiyama, Takumi; Tajima, Takumi; Nagakura, Chisa; Zhong, Yan; Kaise, Toshihiko |
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| 組織名 | Division of Gastroenterology and Hepatology, Department of Internal Medicine, The;Jikei University School of Medicine, Tokyo, Japan.;JMDC Inc., Tokyo, Japan.;Gilead Sciences K.K., Tokyo, Japan.;Gilead Sciences, Inc., Foster City, CA, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41225767/ |
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