| アブストラクト | BACKGROUND: Herpes simplex virus encephalitis(HSE) is a rare but life-threatening condition. While the disease has been well characterized in Western countries, large-scale epidemiological data from Japan are lacking. METHODS: Using the Diagnosis Procedure Combination(DPC) Study Group database, we identified patients hospitalized with HSE between July 2010 and March 2023. Patients were identified using ICD-10 codes. Nationwide incidence was estimated by multiplying the observed case counts by the annual ratio of total discharges in the national MHLW-DPC database to those in the DPC Study Group. We used generalized estimating equations (GEE) to account for clustering within hospitals in multivariable models. In-hospital mortality and functional and neurological outcomes were assessed. Multivariable logistic regression identified prognostic factors. RESULTS: A total of 6,788 patients were identified. The annual incidence of HSE ranged from 5.7 to 8.2 per 100,000 hospitalizations. Overall, in-hospital mortality was 6.0%. Of 6,378 survivors, 2,295 (36.0%) had a Barthel Index score </=90 and 1,602 (25.1%) had impaired consciousness (Japan Coma Scale >/=1) at discharge. A composite poor outcome (death or impaired consciousness) occurred in 2,012 (29.6%). Older age (especially >/=80 years), impaired consciousness at presentation, and comorbidities such as congestive heart failure, chronic renal disease, malignancy, and underweight status were associated with in-hospital mortality and poor outcomes. CONCLUSION: This multicenter analysis of HSV encephalitis in Japan showed that HSV encephalitis in Japan was associated with substantial disability among survivors, in addition to non-negligible mortality. Our findings highlight the need for post-acute rehabilitation to reduce the burden of residual disability. |
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| ジャーナル名 | Journal of epidemiology |
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| Pubmed追加日 | 2025/12/22 |
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| 投稿者 | Kutsuna, Satoshi; Ohbe, Hiroyuki; Kimura, Yuya; Shinmoto, Keito; Matsuo, Yuichiro; Matsui, Hiroki; Fushimi, Kiyohide; Yasunaga, Hideo |
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| 組織名 | Department of Infection Control, Department of Infection Control, Graduate School;of Medicine Faculty of Medicine, Osaka University.;Department of Emergency and Critical Care Medicine, Tohoku University Hospital.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo.;Department of Health Policy and Informatics, Institute of Science Tokyo Graduate;School of Medicine. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41423228/ |
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