| アブストラクト | BACKGROUND: A comprehensive analysis of the respiratory syncytial virus (RSV) burden in England is required. We estimated respiratory-related healthcare resource utilization (HCRU) and costs for infants experiencing RSV episodes. METHODS: A birth cohort of all infants born between March 01, 2015, and February 28, 2017 (n = 449,591) was established using Clinical Practice Research Datalink-Hospital Episode Statistics. Case cohorts included infants with an episode of (1) RSV, (2) bronchiolitis, (3) any respiratory tract infection at <24 months and (4) RSV-predicted at <12 months. Treatments, procedures, clinical outcomes, respiratory-related HCRU and associated costs, and the patient pathway during the month before and 24 months following the index episode were described in case and comparative cohorts. RESULTS: Among the 4813 infants in the RSV-coded case cohort (vs. comparative cohort), the mean number of respiratory-related healthcare visits was 5.1 (vs. 1.5), with the highest burden occurring in November and December, mostly in infants up to 12 months of age. Noninvasive and invasive ventilations were performed in 17% (vs. 0.47%) and 9% (vs.0.28%), respectively, 48% (vs. 38%) were prescribed antibiotics, and 0.44% (vs. 0.09%) died. Before and after the index episode, ~30% and ~75%, respectively, had another respiratory-related healthcare visit, with a mean cost of pound4060 (vs. pound242) per infant. Notably, minimal differences were observed across all outcomes between infants born before and during the RSV season. CONCLUSIONS: This study quantifies the significant impact of RSV infections in infants on the healthcare system. It highlights the need for effective preventive strategies for infants entering their first season. |
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| 投稿者 | Fonseca, Maria Joao; Hagenaars, Saskia; Chetty, Mersha; Bangert, Mathieu; Cirneanu, Lori; Lundbom, Jessica; Hudson, Richard |
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| 組織名 | From the IQVIA, Lisbon, Portugal.;IQVIA, London, United Kingdom.;Sanofi, Reading, United Kingdom.;Sanofi, Lyon, France. |
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