| アブストラクト | OBJECTIVES: The relationships between vaccines and the development of systemic lupus erythematosus (SLE) and related organ involvements remain unclear. METHODS: We analyzed data from the Vaccine Adverse Event Reporting System (VAERS) during the period of 1990 to 2025 to determine the incidence of vaccine-associated SLE over time. The relationships between vaccines and the development of SLE and organ involvements were assessed by disproportionality and case-control analyses. RESULTS: 1976 (0.017%) cases of vaccine-associated lupus were identified amongst 11,301,263 adverse events (AEs) reported in VAERS (1990-2025). Median time from vaccination to symptom onset was 8 (0-8,070) days. The most common manifestations are musculoskeletal and connective tissue disorders (82.94%) followed by skin and subcutaneous tissue lesions (10.83%), while kidney and nervous system involvements are rare. 702 (40.48%) patients had serious outcomes, and 22 (3.13%) died. Human papilloma virus (HPV) vaccine is associated with lupus AEs, especially musculoskeletal/connective tissue disorders, kidney and nervous system involvements. Hepatitis B virus (HBV) vaccine also shows correlations with lupus AEs, particularly musculoskeletal/connective tissue disorders. COVID-19, influenza and zoster vaccines show no relationship with lupus AEs and specific organ involvements. Recombinant protein vaccines show significant links with lupus AEs. CONCLUSION: Vaccine-associated lupus is uncommon and manifestations are generally mild. HPV and HBV vaccines show strong associations with lupus AEs with distinct organ involvements. |
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| ジャーナル名 | Seminars in arthritis and rheumatism |
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| Pubmed追加日 | 2026/1/30 |
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| 投稿者 | Xie, Ruiyan; Cheong, Lai Yee; Zhang, Danting; Wu, Kevin C H; Chan, Shirley C W; Au, Ivan; Leung, Kathy S M; Wu, Joseph T K; Chan, Tak Mao; Yap, Desmond Y H |
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| 組織名 | Division of Nephrology, Department of Medicine, School of Clinical Medicine,;Queen Mary Hospital, The University of Hong Kong, China.;Division of Rheumatology and Clinical Immunology, Department of Medicine, School;of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, China.;School of Public Health, LKS Faculty of Medicine, The University of Hong Kong,;China.;Queen Mary Hospital, The University of Hong Kong, China. Electronic address:;desmondy@hku.hk. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41616382/ |
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