| アブストラクト | INTRODUCTION: This retrospective database study investigated trends in insulin and use of concomitant noninsulin glucose-lowering medication (NIGLM) among Japanese individuals with diabetes. METHODS: The study comprised two analyses: (1) a serial cross-sectional analysis of patterns in insulin treatment by year (database: Real World Data); and (2) a longitudinal retrospective cohort analysis that examined insulin treatment and individuals' characteristics (database: DeSC). Individuals initiating insulin in an inpatient or outpatient setting were followed up for 9 months (type 2 diabetes [T2D]) or 21 months (type 1 diabetes [T1D]) to evaluate treatment changes over time. RESULTS: The serial cross-sectional analysis included 4953 individuals (T2D, n = 4693; T1D, n = 260). The proportion of participants with T2D receiving concomitant NIGLMs increased from 31% in 2002 to 61% in 2021; from 2014 onwards, more than 30% of insulin-treated and basal-insulin-treated individuals treated with concomitant NIGLMs received dipeptidyl peptidase-4 inhibitors. Since 2018, use of concomitant NIGLMs in T1D has increased. The longitudinal retrospective cohort analysis included 27,492 individuals (T2D, n = 27,031; T1D, n = 461). Among participants with T2D who initiated insulin in an inpatient setting, 70.8% received bolus insulin at initiation, with this proportion declining to 17.3% after 9 months; proportions of participants receiving basal insulin and of those receiving basal-bolus insulin increased over the same period (6.3-31.1% and 17.0-23.4%, respectively). The majority of participants with T2D who initiated insulin in an outpatient setting received basal insulin at initiation (hospital, 53.9%; clinic, 58.9%). Among participants with T1D who initiated insulin in an inpatient setting, 57.9% received bolus insulin, and basal-bolus insulin was the predominant regimen after 1 month (85.0%); in outpatient settings, basal-bolus insulin was the predominant regimen throughout the study. CONCLUSION: In Japan, the most prominent insulin regimen at initiation varied across settings in T2D but not in T1D; use of concomitant NIGLMs increased over time in both. |
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| ジャーナル名 | Diabetes therapy : research, treatment and education of diabetes and related disorders |
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| Pubmed追加日 | 2026/1/28 |
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| 投稿者 | Fukui, Michiaki; Tsuboi, Satoshi; Yamamoto, Yuiko; Terauchi, Yasuo |
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| 組織名 | Graduate School of Medical Science, Kyoto Prefectural University of Medicine,;Kyoto, Japan.;Novo Nordisk Pharma Ltd, Tokyo, Japan.;Novo Nordisk Pharma Ltd, Tokyo, Japan. yuya@novonordisk.com.;Yokohama City University Graduate School of Medicine, Yokohama, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41593302/ |
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