| アブストラクト | BACKGROUND: Keloids are rare but challenging complications in penile surgeries, including circumcision. The President's Emergency Plan for AIDS Relief (PEPFAR) supports voluntary medical male circumcisions (VMMC) for HIV prevention in sub-Saharan Africa, and has monitored major adverse events through its Notifiable Adverse Event Reporting system (NAER) since 2015, providing unique opportunities to understand keloid epidemiology and risk factors. METHODS: All 2015-2023 NAER keloid cases were reviewed. Variables abstracted included age at VMMC, time course, and case characteristics. Descriptive analysis and Fisher's exact test of the association between client age (< 15 years vs. >/= 15 years) and keloids were performed. Systematic literature searches were also conducted on case reports, outcomes and management guidelines, to produce a narrative summary and comparisons between the NAER cases and prior literature. RESULTS: Eleven cases were reported. Clients were < 15 years old in 10/11, with median age 12 years and mean time to diagnosis 1.8 years. Clients aged 10-14 years had a significantly higher risk for keloids compared to those aged 15 and older (p = 0.0004). Case characteristics were similar to those in prior case series, as was management, except that silicone gels or sheeting were not used. Follow-up was too brief to assess outcomes. CONCLUSIONS: Keloids were a rare complication of PEPFAR-supported VMMCs. Keloids were strongly associated with age 10-14 years at circumcision as compared to older age. Programs can remind clients to return to VMMC sites even for late complications, and develop expert referral networks. Silicone gels or sheeting could represent an additional conservative management option. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12894-025-01949-7. |
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| 投稿者 | Davis, Stephanie; Akom, Eniko; Kiggundu, Valerian; Nabukera, Sarah; Thomas, Anne; Simbeye, Daimon; Rwabiyago, Oscar Ernest; Mmbando, Suzan; Kayange, Alick; Fida, Neway; Mandisarisa, John; Mhuka, Tungamirai; Msungama, Wezi; Kapito, Martin; Matchere, Faustin; Maulidi, Martin; Odoyo-June, Elijah; Soo, Leonard; Juma, Ambrose; Lucas, Todd |
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| 組織名 | Division of Global HIV and Tuberculosis, United States Centers for Disease;Control and Prevention, Atlanta, GA, USA. vic6@cdc.gov.;HIV Prevention Branch, Division of Global HIV and Tuberculosis, Department of;Health and Human Services (HHS), U.S. Centers for Disease Control and Prevention;(CDC), Atlanta, USA. vic6@cdc.gov.;Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.,;Bethesda, MD, USA.;U.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research,;Silver Spring, MD, USA.;Global Health Consultant, Washington, DC, USA.;Office of Program Quality, The U.S. President's Emergency Plan for AIDS Relief;(PEPFAR), Bureau of Global Health Security and Diplomacy (GHSD), Washington, DC,;USA.;U.S. Department of Defense HIV/AIDS Prevention Program, Defense Health Agency,;San Diego, CA, USA.;Control and Prevention, Dar es Salaam, Tanzania.;Ministry of Health, Dar es Salaam, Tanzania.;United States Department of Defense, Dar es Salaam, Tanzania.;United States Agency for International Development, Dar es Salaam, Tanzania.;Control and Prevention, Harare, Zimbabwe.;Zimbabwe Technical Assistance, Training and Education Center for Health;(ZIMTTECH), Harare, Zimbabwe.;Control and Prevention, Lilongwe, Malawi.;Ministry of Health, Lilongwe, Malawi.;United States Department of Defense, Lilongwe, Malawi.;United States Agency for International Development, Lilongwe, Malawi.;Control and Prevention, Nairobi, Kenya.;United States Agency for International Development, Nairobi, Kenya.;Ministry of Health, Nairobi, Kenya.;Control and Prevention, Atlanta, GA, USA. |
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