| アブストラクト | BACKGROUND: Although the COVID-19 pandemic altered hospitalization trends for acute cardiovascular diseases (CVD) in Japan, the effects of a concomitant COVID-19 diagnosis on mortality in this high-risk population remains unclear. We investigated the association between COVID-19 infection and 30-day mortality among patients hospitalized for acute CVD using a nationwide database. METHODS AND RESULTS: This retrospective cohort study used data from the Japanese Registry of All Cardiac and Vascular Diseases-Diagnosis Procedure Combination (JROAD-DPC) database from January 2020 to March 2022. We included patients hospitalized for acute myocardial infarction, acute heart failure, aortic rupture, or venous thromboembolism. We compared patients with and without COVID-19, with 30-day mortality as the primary outcome. We used 1 : 1 propensity score matching to balance baseline patient and hospital characteristics. Of 395,671 eligible patients in the JROAD-DPC database, 41,794 (10.6%) had a concomitant COVID-19 diagnosis. In the matched cohort of 41,794 pairs, the risk of 30-day mortality was significantly higher patients for patients with than without COVID-19 (6.6% vs. 5.8%; odds ratio 1.14; 95% confidence interval 1.08-1.21; P<0.001). This increased risk was consistent across all major diagnostic subgroups (P for interaction >0.3). CONCLUSIONS: In this large nationwide study of patients hospitalized for acute CVD in Japan, concomitant COVID-19 infection was associated with a significant increase in 30-day mortality. These findings suggest that COVID-19 infection is associated with increased mortality in this vulnerable patient population. |
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| ジャーナル名 | Circulation reports |
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| Pubmed追加日 | 2026/2/11 |
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| 投稿者 | Sugimoto, Tadafumi; Mizuno, Atsushi; Yoneoka, Daisuke; Matsumoto, Shingo; Matsumoto, Chisa; Matsue, Yuya; Ishida, Mari; Kanaoka, Koshiro; Iwanaga, Yoshitaka; Miyamoto, Yoshihiro; Node, Koichi |
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| 組織名 | Department of Cardiology, Nagoya City University Mirai Kousei Hospital Nagoya;Japan.;Department of Cardiology and Nephrology, Mie University Graduate School of;Medicine Mie Japan.;Department of Cardiovascular Medicine, St. Luke's International Hospital Tokyo;Penn Medicine Nudge Unit, University of Pennsylvania PA USA.;Leonard Davis Institute for Health Economics, University of Pennsylvania PA USA.;Department of Epidemiology, National Institute of Infectious Diseases, Japan;Institute for Health Security Tokyo Japan.;Division of Cardiovascular Medicine, Department of Internal Medicine, Toho;University Faculty of Medicine Tokyo Japan.;Department of Cardiology, Center for Health Surveillance and Preventive Medicine,;Tokyo Medical University Tokyo Japan.;Department of Cardiology, Tokyo Medical University Tokyo Japan.;Department of Cardiovascular Biology and Medicine, Juntendo University Graduate;School of Medicine Tokyo Japan.;Department of Cardiovascular Physiology and Medicine, Graduate School of;Biomedical and Health Sciences, Hiroshima University Hiroshima Japan.;Department of Medical and Health Information Management, National Cerebral and;Cardiovascular Center Osaka Japan.;Department of Cardiology, Sakurabashi-Watanabe Hospital Osaka Japan.;Open Innovation Center, National Cerebral and Cardiovascular Center Osaka Japan.;Department of Cardiovascular Medicine, Saga University Saga Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41669520/ |
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