| アブストラクト | BACKGROUND: Hypertension is a common comorbidity among patients undergoing knee arthroplasty and has been associated with postoperative complications; however, its clinical impact in Japanese populations remains unclear. This study evaluated the association between hypertension and in-hospital complications following total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA). METHODS: A retrospective cohort study was conducted using Japan's nationwide Diagnosis Procedure Combination database (April 2016-March 2023). Postoperative outcomes-including deep vein thrombosis (DVT), pulmonary embolism (PE), cerebrovascular events, surgical site infection, and periprosthetic fracture-were compared between hypertension and non-hypertension groups. Propensity score (PS) matching (1:1) was performed using demographic variables, comorbidities, anesthesia type, and surgical procedure. Multivariate logistic regression was used to identify independent predictors of DVT. RESULTS: Of 257,319 eligible patients, PS matching yielded 77,637 patients per group. Hypertension was associated with a significantly higher incidence of DVT after matching, with an absolute risk difference of 1.82 %. Although hypertension was also associated with an increased relative risk of surgical site infection, the absolute risk difference was modest (0.46 %). Logistic regression identified hypertension (Odds ratio: 1.24; 95 % CI: 1.20-1.29) as an independent risk factor for DVT. Hypertension was also associated with longer hospitalization and greater transfusion volume on the day of surgery. Sensitivity analyses confirmed these findings. CONCLUSION: Hypertension independently increased the risk of postoperative complications after knee arthroplasty, particularly DVT. Although hypertension increased the relative risk of surgical site infection, the absolute risk difference was modest. These findings highlight the importance of perioperative risk stratification and venous thromboembolism prevention in patients with hypertension. |
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| ジャーナル名 | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association |
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| Pubmed追加日 | 2026/2/17 |
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| 投稿者 | Mori, Yu; Tarasawa, Kunio; Tanaka, Hidetatsu; Kanabuchi, Ryuichi; Mori, Naoko; Fushimi, Kiyohide; Aizawa, Toshimi; Fujimori, Kenji |
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| 組織名 | Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine,;1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address:;yu.mori.c4@tohoku.ac.jp.;Department of Health Administration and Policy, Tohoku University Graduate School;of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.;Electronic address: kunio.tarasawa.b6@tohoku.ac.jp.;hidetatsu.tanaka.c7@tohoku.ac.jp.;ryuichi.kanabuchi.b8@tohoku.ac.jp.;Department of Radiology, Akita University Graduate School of Medicine, 1-1-1;Hondo, Akita, Akita, 010-8543, Japan. Electronic address:;naokomori7127@gmail.com.;Department of Health Policy and Informatics, Institute of Science Tokyo, 1-5-45;Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Electronic address:;kfushimi.hci@tmd.ac.jp.;toshimi.aizawa.a5@tohoku.ac.jp.;Electronic address: kenji.fujimori.e5@tohoku.ac.jp. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41698867/ |
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