| アブストラクト | INTRODUCTION: Inflammatory bowel disease (IBD) and colorectal cancer (CRC) share overlapping symptoms. Faecal Immunochemical Test (FIT) is mandated in UK primary care to triage symptomatic patients suspected of CRC, but the extent to which IBD is identified in these patients remains unclear. We aim to assess the one-year IBD diagnosis rate in symptomatic patients following FIT for suspected CRC, and how this varies with age, FIT, and faecal calprotectin (FCP). METHODS: A population-based cohort study of symptomatic patients undergoing FIT in the UK Clinical Practice Research Datalink (CPRD) (January 2019-June 2023), with one-year follow-up was conducted. Kaplan-Meier estimates were used to assess cumulative one-year IBD-risk, stratified by age, FIT, and FCP results. RESULTS: 2762 of 473402 (0.58%) patients were diagnosed with IBD within one-year of FIT. Patients under 50 years (N=110501) accounted for 53.6% of all IBD diagnoses, but only 6.9% of all CRC diagnoses (N=347). Overall IBD-risk was 2.3% with FIT>/=10microgHb/g compared to 0.1% with FIT<10microgHb/g. Among 63469 patients with elevated FCP and FIT, IBD-risk in those under 50 years was 21.0% when FIT>/=10microgHb/g and FCP>50microg/g. The combined risk of CRC or IBD in those with FIT>/=10microgHb/g was 7.1%. This fell to 3.3% in the subset of patients who also had FCP </=50microg/g. CONCLUSION: IBD is more common than CRC in patients under 50 years referred on symptomatic FIT pathways using a FIT>/=10microgHb/g threshold. In a selected cohort of dual-tested patients, FCP provided additional risk stratification. Incorporating routine FCP into symptomatic FIT pathways may better target further investigations. |
|---|
| ジャーナル名 | The British journal of surgery |
|---|
| Pubmed追加日 | 2026/3/26 |
|---|
| 投稿者 | Ng, James Chean Khun; Morton, Alastair J; Crooks, Colin J; West, Joe; Grainge, Matthew J; Card, Timothy R; Humes, David J |
|---|
| 組織名 | Colorectal Service, Nottingham University Hospital NHS Trust, Queen's Medical;Centre, Nottingham, NG7 2UH, United Kingdom.;School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham,;NG7 2UH, United Kingdom.;National Institute for Health Research (NIHR) Nottingham Biomedical Research;Centre (BRC), Nottingham University Hospital NHS Trust and the University of;Nottingham, School of Medicine, Queen's Medical Centre, Nottingham, NG7 2UH,;United Kingdom.;Lifespan and Population Health, School of Medicine, University of Nottingham,;Department of Clinical Medicine - Hepatology and Gastroenterology, Palle;Juul-Hensens Boulevard 35, 8200 Aarhus N, Denmark.;Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory;Agency, United Kingdom. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41886598/ |
|---|
