| アブストラクト | BACKGROUND: Depression is common in patients with chronic kidney disease (CKD) and known to be associated with a greater risk of developing cardiovascular disease (CVD). However, it is uncertain whether, and to what extent, depression influences the incidence of CVD among individuals with CKD. METHODS AND RESULTS: We analyzed 281,961 individuals with CKD defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) or proteinuria (>/= +1) including 14,527 (5.2%) individuals with depression registered in the DeSC database from April 2014 to August 2023. The DeSC database is commercially available from DeSC Healthcare Inc. A Cox proportional hazards regression analysis was conducted to estimate the hazard ratio associated with the presence of depression. The median age was 68 years and 47.8% were men. During the follow-up period, 48,359 composite CVD events were recorded. Multivariable Cox regression analysis showed that CKD individuals with depression had a greater risk of composite CVD events than those without (hazard ratio 1.36; 95% confidence interval 1.31-1.42). Given the limitations of real-world data, we performed multiple sensitivity analyses, which confirmed the results of our primary analysis. Notably, we found that the association between depression and a subsequent risk of developing CVD was not modified by eGFR. CONCLUSIONS: Depression is independently associated with an increased risk of CVD among individuals with CKD regardless of baseline kidney function. |
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| ジャーナル名 | Circulation reports |
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| Pubmed追加日 | 2026/5/11 |
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| 投稿者 | Kuroyanagi, Daiki; Kaneko, Hidehiro; Suzuki, Yuta; Okada, Akira; Morita, Hiroyuki; Takeda, Norifumi; Fujiu, Katsuhito; Komuro, Kaoruko; Ko, Toshiyuki; Mitsuno, Ryunosuke; Nakayama, Takashin; Azegami, Tatsuhiko; Hayashi, Kaori; Yasunaga, Hideo; Takeda, Norihiko; Kawamura, Akio |
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| 組織名 | International University of Health and Welfare, School of Medicine Chiba Japan.;Department of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.;Department of Advanced Cardiology, The University of Tokyo Tokyo Japan.;Center for Outcomes Research and Economic Evaluation for Health, National;Institute of Public Health Saitama Japan.;Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate;School of Medicine, The University of Tokyo Tokyo Japan.;Department of Integrative Physiology, Institute of Science Tokyo Tokyo Japan.;Department of Cardiology, Keio University School of Medicine Tokyo Japan.;Department of Frontier Cardiovascular Science, Graduate School of Medicine, The;University of Tokyo Tokyo Japan.;Division of Endocrinology, Metabolism and Nephrology, Department of Internal;Medicine, Keio University School of Medicine Tokyo Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo Tokyo Japan.;Department of Cardiology, International University of Health and Welfare, School;of Medicine Chiba Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42110869/ |
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