| アブストラクト | In this pharmacovigilance study, we aimed to identify the primary suspected drugs associated with drug-induced noninfectious myocarditis/pericarditis by analyzing adverse event reports in the FDA Adverse Event Reporting System database from 2004 to 2023. This study utilizes "Noninfectious Myocarditis/Pericarditis" as a standardized MedDRA query (SMQ), employing the reporting odds ratio, proportional reporting ratio, and Bayesian Confidence Propagation Neural Network methods at the SMQ and Preferred Term levels to monitor potential drug signals, and provides a comprehensive overview of medications associated with drug-induced noninfectious myocarditis/pericarditis. A total of 21,422 relevant adverse event reports were identified, among which 953 drugs were reported as primary suspects. Disproportionality analysis using the reporting odds ratio, proportional reporting ratio, and Bayesian confidence propagation neural network methods revealed 193, 163, and 176 drugs, respectively, with potential signals of drug-induced noninfectious myocarditis/pericarditis. Notably, clozapine emerged as the most frequently reported drug, followed by nivolumab and pembrolizumab. Immune checkpoint inhibitors used in antitumor therapy represented the highest proportion of the drug category among the top 30 drugs implicated in adverse event reports. Our findings contribute to a better understanding and prevention of myocarditis/pericarditis, offering valuable reference information for clinical practice. |
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| ジャーナル名 | Cardiovascular toxicology |
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| Pubmed追加日 | 2026/5/22 |
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| 投稿者 | Zhao, Shijie; Chen, Weiyi; Tao, Chao; Wang, Ke; Yang, Liuxuan; Li, Ruixiao; Zhou, Meiling; Shang, Jinlu; Liu, Xianbin |
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| 組織名 | Department of Clinical Research, Sichuan Clinical Research Center for Cancer,;Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of;Electronic Science and Technology of China, Chengdu, 610041, China.;College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese;Medicine, Guiyang, 550025, China.;Department of Pharmacy, The Affiliated Hospital, Southwest Medical University,;Luzhou, 646000, China.;Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical;University, Luzhou, 646000, China.;Department of Pharmacy, West China Hospital Sichuan University Jintang Hospital .;Jintang First People's Hospital, Chengdu, 610400, China. 1358805239@qq.com.;Department of Pharmacy, Mianyang Central Hospital, School of Medicine, University;of Electronic Science and Technology of China, Mianyang, Sichuan, People's;Republic of China. lxb199511@163.com. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42168451/ |
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