| アブストラクト | BACKGROUND: While international guidelines recommend 5-10% body weight reduction, evidence characterizing the dose-response relationship between specific weight loss amounts and metabolic syndrome (MetS) resolution in real-world populations is limited. METHODS AND RESULTS: In this retrospective study, we analyzed a large-scale health check-up database provided by DeSC Healthcare (Tokyo, Japan). We identified 37,256 individuals with baseline MetS eligible for the Specific Health Guidance (SHG) program (2014-2023). Logistic regression assessed the association between 1-year weight changes and subsequent MetS status. Weight loss was significantly linked to MetS resolution. Compared with weight maintenance, a weight loss of 2.0-2.9 kg showed an adjusted odds ratio (OR) of 0.45 (95% confidence interval [CI] 0.41-0.49), and a loss of >/=3.0 kg showed an OR of 0.19 (95% CI 0.18-0.21). These associations were consistent across age and sex subgroups. Secondary analyses confirmed significant improvements in waist circumference, blood pressure, lipid profiles, and HbA1c. CONCLUSIONS: Weight loss over 1 year is significantly associated with MetS resolution among SHG-eligible individuals. These findings support the validity of weight loss recommendations in the fourth phase of the SHG program and offer empirical data for future health guidance design. |
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| ジャーナル名 | Circulation reports |
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| Pubmed追加日 | 2026/6/11 |
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| 投稿者 | Nishikawa, Masachika; Suzuki, Yuta; Ko, Toshiyuki; Kaneko, Hidehiro; Okada, Akira; Takeda, Norifumi; Morita, Hiroyuki; Fujiu, Katsuhito; Azegami, Tatsuhiko; Hayashi, Kaori; Kitaoka, Kaori; Miura, Katsuyuki; Furui, Yuji; Node, Koichi; Yasunaga, Hideo; Nangaku, Masaomi; Takeda, Norihiko |
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| 組織名 | Department of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.;Center for Outcomes Research and Economic Evaluation for Health, National;Institute of Public Health Saitama Japan.;Department of Advanced Cardiology, The University of Tokyo Tokyo Japan.;Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate;School of Medicine, The University of Tokyo Tokyo Japan.;Division of Nephrology, Endocrinology and Metabolism, Department of Internal;Medicine, Keio University School of Medicine Tokyo Japan.;Section of Research Collaboration and Partnership, Center for;Private-Public-Academic Collaboration Research, National Institutes of Biomedical;Innovation, Health and Nutrition Osaka Japan.;NCD Epidemiology Research Center, Shiga University of Medical Science Shiga;Japan.;Department of Public Health, Shiga University of Medical Science Shiga Japan.;Healthcare Data Science Research Unit, Institute for Future Initiatives, The;University of Tokyo Tokyo Japan.;Department of Cardiovascular Medicine, Saga University Saga Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo Tokyo Japan.;Division of Nephrology and Endocrinology, The University of Tokyo Graduate School;of Medicine Tokyo Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42273303/ |
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