| アブストラクト | Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist in elderly patients. Surgical aortic valve replacement (SAVR) with coronary artery bypass grafting (CABG) has been the standard treatment. However, transcatheter aortic valve replacement (TAVR) combined with percutaneous coronary intervention (PCI) currently offers a less invasive alternative. This study describes in-hospital and functional outcomes in elderly patients with AS and CAD undergoing TAVR + PCI or SAVR + CABG, and evaluates procedural volume influence. This retrospective cohort study analyzed 12,393 patients from the Japanese Registry of All Cardiac and Vascular Diseases-Diagnosis Procedure Combination database (2012-2022) who underwent TAVR + PCI (n = 1,487) or SAVR + CABG (n = 10,906) during hospitalization for AS. The primary endpoint was in-hospital mortality rate. Secondary outcomes included functional recovery, assessed using the Barthel Index (BI). Multivariate logistic regression models were adjusted for demographics, comorbidities, and procedural volume. Patients in the TAVR + PCI group were older (85.1 vs. 75.5 years) and had higher frailty. However, in-hospital mortality was lower in TAVR + PCI (3.3% vs. 5.1%, p = 0.002), with greater improvements in BI scores at discharge (+ 5.9 vs. - 1.9, p < 0.001). SAVR + CABG outcomes improved significantly at high-volume Centers (adjusted OR for mortality in the lowest vs. highest quartile: 2.067, p < 0.001). In contrast, TAVR outcomes were consistent regardless of institutional procedural volume. TAVR + PCI was associated with favorable short-term outcomes and functional recovery in elderly AS patients with CAD, despite older age and greater frailty. Institutional experience strongly influences SAVR outcomes, but appears less critical in TAVR, suggesting that TAVR can be safely performed at more hospitals. |
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| ジャーナル名 | Cardiovascular intervention and therapeutics |
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| Pubmed追加日 | 2026/6/30 |
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| 投稿者 | Takagi, Kensuke; Mitsui, Kentaro; Sumita, Yoko; Kanaoka, Koshiro; Miyamoto, Yoshihiro; Fukushima, Satsuki; Yamamoto, Kazuhiro; Noguchi, Teruo |
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| 組織名 | Department of Cardiovascular Medicine, National Cerebral and Cardiovascular;Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.;takagi.kensuke@ncvc.go.jp.;Department of Cardiac Surgery, National Cerebral and Cardiovascular Center,;Suita, Osaka, Japan.;Department of Medical and Health Information Management, National Cerebral and;Cardiovascular Center, Suita, Osaka, Japan.;Division of Cardiovascular Medicine, Endocrinology and Metabolism, Tottori;University, Yonago, Tottori, Japan.;Department of Advanced Cardiovascular Medicine, Graduate School of Medical;Sciences, Kumamoto University, Kumamoto, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42377802/ |
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