Urinary tract infections, urosepsis, and multiple sclerosis disease modifying therapies: a disproportionality analysis of the FDA Adverse Event Reporting System.

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Urinary tract infections, urosepsis, and multiple sclerosis disease modifying therapies: a disproportionality analysis of the FDA Adverse Event Reporting System.

アブストラクト	Infection-related complications, including urinary tract infections (UTIs) and urosepsis, account for a significant proportion of morbidity and mortality in patients with advanced multiple sclerosis (MS). However, the role of specific disease-modifying therapies (DMTs) in UTI and urosepsis risks remains underexplored. We identified 12,997 UTI and 651 urosepsis reports associated with various MS in the FDA Adverse Event Reporting System. Ocrelizumab exhibited the greatest safety signal for UTI, while natalizumab, alemtuzumab, and interferon beta-1a were also associated with disproportionately high reporting across sex and age subgroups. Thus, clinicians should maintain UTI vigilance and integrate proactive bladder management in routine MS care.
ジャーナル名	Multiple sclerosis and related disorders
Pubmed追加日	2026/7/12
投稿者	Balshi, Alexandra; Esser, Madelyn; Kaplan, Tamara B
組織名	Harvard Medical School, Boston, MA, USA.;Boston College, Chestnut Hill, MA, USA.;Harvard Medical School, Boston, MA, USA; Department of Neurology, Mass General;Brigham Inc, Boston, MA, USA. Electronic address: tbkaplan@bwh.harvard.edu.
Pubmed リンク	https://www.ncbi.nlm.nih.gov/pubmed/42435648/