| アブストラクト | Hypochondroplasia is a rare genetic condition that causes disproportionate short stature. This retrospective, real-world, matched-cohort study used electronic health records data from the Clinical Practice Research Datalink Aurum primary care database, linked to Hospital Episode Statistics and Office of National Statistics mortality records, to assess the natural history of hypochondroplasia in England from 1998 to 2019. A total of 549 participants with hypochondroplasia and 2196 matched controls were included. Mean follow-up time was 7.50 years for participants with hypochondroplasia and 11.68 years for controls. Approximately 60% of participants were aged >18 years at start of follow-up. Mean age (standard deviation) at first recorded hypochondroplasia code was 29.20 (20.2) years. The highest event rates for participants with hypochondroplasia involved cardiovascular, orthopaedic, respiratory, mental health, and ear, nose and throat (ENT) systems. Event rates for the selected comorbidities combined were higher in participants with hypochondroplasia versus controls (rate ratio [RR] 2.13, 95% confidence interval [CI] 1.98-2.28). Participants with hypochondroplasia had higher healthcare visit rates, including a median of 10.91 annual general practitioner visits versus 5.52 for controls (RR 1.63, 95% CI 1.48-1.80). Mortality rates were more than double for participants with hypochondroplasia versus controls (RR 2.64, 95% CI 1.33-5.26), mainly driven by cohorts aged >/=30 years and by cardiovascular and respiratory diseases. Rates for procedures, particularly orthopaedic and ENT, and medication use were also higher among participants with hypochondroplasia versus controls. These results highlight the medical burden of hypochondroplasia and need for coordinated, multidisciplinary management starting early in life. |
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| ジャーナル名 | Bone |
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| Pubmed追加日 | 2026/7/17 |
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| 投稿者 | Reddy, Sheila R; Pimenta, Jeanne M; Shepherd, Hilary; Sutton, Jaim; Cheung, Moira; Irving, Melita; Mukherjee, Swati; Axson, Eleanor L; Williams, Rachael |
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| 組織名 | BioMarin Pharmaceutical Inc., 770 Lindaro Street, San Rafael, CA, 94901, USA.;Electronic address: Sheila.Reddy@bmrn.com.;BioMarin (UK) Ltd, 10 Bloomsbury Way, London, WC1A 2SL, UK. Electronic address:;Jeanne.Pimenta@bmrn.com.;Clinical Practice Research Datalink (CPRD), Medicines and Healthcare products;Regulatory Agency (MHRA), 10 South Colonnade, Canary Wharf, London, UK.;Electronic address: Hilary.Shepherd@mhra.gov.uk.;jaim.sutton@gmail.com.;NIHR Great Ormond Street Hospital Biomedical Research Centre, University College;London, Guilford St, London, WC1N 3BH, UK. Electronic address:;moira.cheung@gosh.nhs.uk.;Myriad Trials, 3-4 Devonshire Street, London, W1W 5DT, UK. Electronic address:;melita@myriadtrials.com.;swati.mukherjee@bmrn.com.;Electronic address: Eleanor.Axson@mhra.gov.uk.;Electronic address: Rachael.Williams@mhra.gov.uk. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42462837/ |
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