| アブストラクト | OBJECTIVE: Idiopathic inflammatory myopathies (IIM) are a heterogenous group of conditions with substantial morbidity but population-based epidemiology is lacking. We aimed to provide a contemporary epidemiological assessment of IIM. METHODS: Population-based study using the Clinical Practice Research Datalink (CPRD) Aurum primary care database with linkage to hospital episode data. All patients (aged >2 years) from England registered between 1 March 2002 and 31 March 2021 were included. Incidence was estimated for three main IIM subtypes: dermatomyositis (DM), inclusion body myositis (IBM) and other IIM. Incidence rate ratios using Poisson models were compared across subgroups. RESULTS: We identified n=1590 DM, n=432 IBM and n=2083 other IIM incident cases. Incidence of DM was 0.79 (95% CI 0.75 to 0.83), IBM 0.50 (95% CI 0.46 to 0.55) and other IIM 1.03 (95% CI 0.99 to 1.08) per 100 000 person-years.Females had a higher incidence of DM (adjusted incidence rate ratio (aIRR) 1.84, 95% CI 1.66 to 2.04) and other IIM (aIRR 1.09, 95% CI 1.00 to 1.19), but a lower incidence of IBM (aIRR 0.73, 95% CI 0.60 to 0.89), compared with males. South Asian, black, other and unknown ethnic groups had a higher incidence of DM and other IIM compared with those of white ethnicity, particularly individuals of black ethnicity for other IIM (aIRR 2.80, 95% CI 2.32 to 3.37).Point prevalence at study end was 0.015% for DM, 0.005% for IBM and 0.016% for other IIM. CONCLUSION: There are major demographic differences in IIM incidence, notably by sex and ethnicity. Resource planning should account for these marked differences. |
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| ジャーナル名 | RMD open |
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| Pubmed追加日 | 2026/7/16 |
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| 投稿者 | Gordon, Patrick; McLean, Michael; Czachorowski, Maciej; Xenakis, Jason; Barkaway, Anna; Rana, Saqib; Bahit, Serhan; Curtis, Charlotte; Hannah, Jennifer; Galloway, James |
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| 組織名 | Department of Academic Rheumatology, King's College London, London, UK.;Department of Rheumatology, King's College London, London, UK.;Pfizer Ltd, Tadworth, UK.;Momentum Data Ltd, St. Albans, UK.;Department of Rheumatology, Surrey and Sussex Healthcare NHS Trust, Redhill, UK.;Department of Academic Rheumatology, King's College London, London, UK;james.galloway@kcl.ac.uk. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42457214/ |
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