| アブストラクト | Polypharmacology is dedicated to the development of compounds acting on at least two targets (multi-target-directed ligands, MTDLs). In 2025, the European Medicines Agency (EMA) approved 38 drugs, and 11 out of them were MTDLs. Most of them are antibody-drug conjugates, bispecific antibodies, or kinase inhibitors, all of which are indicated for tumor treatment, including datopotamab deruxtecan (hormone receptor-positive, HER2-negative breast cancer), tisotumab vedotin (advanced cervical carcinoma), linvoseltamab (fourth-line treatment of multiple myeloma), and erdafitinib (advanced urothelial carcinoma). The small molecule tiratricol is an orphan drug, which is indicated for the treatment of the very rare Allan-Herndon-Dudley syndrome. The second part of the present review is dedicated to the post-marketing safety surveillance of MTDLs approved by the EMA in 2022-2024. For 19 out of the 27 MTDLs, which are still available on the European market, comprehensive pharmacovigilance studies, mainly based on the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS), were found. New safety signals have been identified, including Stevens-Johnson syndrome and progressive multifocal leukoencephalopathy. The analysis also revealed a more favorable safety profile of the MTDL tirzepatide (a dual glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide analogue) compared to the single-targeted drug semaglutide (glucagon-like peptide-1 analogue), including lower reporting rates of acute kidney injury and no significant suicidality signal. |
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| ジャーナル名 | Pharmacological reports : PR |
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| Pubmed追加日 | 2026/7/22 |
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| 投稿者 | Ryszkiewicz, Piotr; Baranowska-Kuczko, Marta; Malinowska, Barbara; Schlicker, Eberhard |
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| 組織名 | Department of Experimental Physiology and Pathophysiology, Medical University of;Bialystok, Mickiewicza 2A, Bialystok, 15-222, Poland.;piotr.ryszkiewicz@umb.edu.pl.;Department of Experimental Physiology and Pathophysiology, Department of Clinical;Pharmacy, Medical University of Bialystok, Mickiewicza 2A, Bialystok, 15-222,;Poland.;Department of Pharmacology and Toxicology, University of Bonn, Venusberg Campus;1, 53127, Bonn, Germany. e.schlicker@uni-bonn.de. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42484993/ |
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