| アブストラクト | BACKGROUND: Etomidate is a widely used intravenous anesthetic, yet concerns persist regarding its potential for adverse drug reactions (ADRs) beyond well-known adrenal suppression. Pre-marketing trials may not fully capture its long-term or rare safety profile, necessitating continuous post-marketing surveillance. METHODS: A retrospective pharmacovigilance study was performed based on the U.S. FDA Adverse Event Reporting System (FAERS) database (Q1 2004-Q2 2025). Disproportionality analysis using ROR, PRR, BCPNN and EBGM algorithms was conducted and the corresponding 95% CIs were calculated. ADRs meeting the criteria of all four algorithms were considered positive signals significantly associated with the target drug. RESULTS: Totally 318 ADRs were acquired, of which 59 preferred terms (PTs) and two system organ classes (SOCs) met four algorithm criteria. In addition to known cardiovascular, muscular and adrenal related PTs, novel positive signals included cardiac arrest (n = 33), seizure (n = 12), drug abuse (n = 10), hypokalaemia (n = 9) and bruxism (n = 9) were found to be correlated with etomidate. As for SOCs, cardiac disorders (n = 100) remains significantly associated with etomidate while endocrine disorders (n = 38) was uncovered as a novel signal. CONCLUSIONS: This study confirmed known risks and identified novel ADRs of etomidate. These findings underscore the need for heightened clinical vigilance and further investigation into its long-term safety profile. |
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| ジャーナル名 | Frontiers in medicine |
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| Pubmed追加日 | 2026/7/22 |
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| 投稿者 | Deng, Huiyi; Lai, Wujiang; Xiang, Ying; Wang, Zewen; Liang, Jiemei; Zhang, Yiwen; Liang, Jiale |
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| 組織名 | Department of Gynecology, the Eighth Affiliated Hospital of Southern Medical;University (The First People's Hospital of Shunde), Foshan, Guangdong, China.;Senior Department of Traditional Chinese Medicine, the Sixth Medical Center of;PLA General Hospital, Beijing, China.;Department of Anesthesiology, the Eighth Affiliated Hospital of Southern Medical |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42482892/ |
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