| アブストラクト | BACKGROUND: Several studies have reported the potential effectiveness of indocyanine green fluorescence angiography (ICG-FA) for preventing anastomotic leakage (AL) in rectal cancer surgery; however, its clinical benefit remains uncertain. The purpose of this study was to investigate the effectiveness of ICG-FA in rectal cancer surgery in Japan using real-world data. METHODS: We retrieved data from the Diagnosis Procedure Combination database in Japan for rectal cancer surgeries between April 2018 and March 2022. A total of 68,022 cases were registered, and 55,299 eligible patients were analyzed. Using a two-level structure of nested individuals from 1,057 hospitals, we applied multilevel logistic regression. RESULTS: A total of 40,013 laparoscopic (72.4%), 7,464 robotic (13.5%), and 7,822 open (14.1%) operations were performed. The rate of AL was 4.3% in the ICG-FA group and 5.1% in the non-ICG-FA group. After adjustment for patient- and hospital-level factors, ICG-FA was associated with a lower risk of AL (OR 0.87, 95% CI 0.76-1.00, p = 0.043); however, after additional adjustment for fiscal year, the association was no longer statistically significant (OR 0.91, 95% CI 0.79-1.04, p = 0.167). CONCLUSIONS: ICG-FA may be associated with a lower risk of AL after rectal cancer surgery in real-world settings, although the benefit was not statistically significant after additional adjustment for fiscal year. |
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| ジャーナル名 | Journal of the anus, rectum and colon |
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| Pubmed追加日 | 2026/8/2 |
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| 投稿者 | Amaike, Takao; Okawara, Makoto; Akiyama, Yasuki; Nagata, Jun; Nitta, Kensuke; Yamauchi, Masumi; Fujino, Yoshihisa; Shibao, Kazunori; Fushimi, Kiyohide; Matsuda, Shinya; Hirata, Keiji |
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| 組織名 | Department of Surgery 1, School of Medicine, University of Occupational and;Environmental Health, Kitakyushu, Japan.;Department of Preventive Medicine and Community Health, University of;Occupational and Environmental Health, Kitakyushu, Japan.;Department of Environmental Epidemiology, Institute of Industrial Ecological;Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.;Department of Health Policy and Informatics, Institute of Science Tokyo, Tokyo,;Japan.;Department of Nursing, Fukuoka International University of Health and Welfare,;Fukuoka, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42539946/ |
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