| アブストラクト | INTRODUCTION: Erythema multiforme (EM) is a rare immune-mediated skin condition often triggered by infections, drugs, or autoimmune diseases. Age-related differences in drug exposure, comorbidities, and biological factors may affect adverse event reporting patterns; however, age-related patterns in EM onset remain unclear. This study investigated age-related patterns in reported time-to-onset of EM. METHODS: The observation period was defined as 1-180 days from the initiation of drug administration. Kendall's tau-b rank correlation analysis was used to evaluate the association between ordered age categories and reported time to onset. The Kaplan-Meier method with a log-rank test was used to compare EM onset profiles between two age groups (<60 and >/=60 years). RESULTS: A positive association was observed between age category and reported time-to-onset (Kendall's tau-b = 0.188, p < 0.001). The median time-to-onset was 10.0 days in both men and women, although the Kaplan-Meier curves differed significantly by sex (log-rank p = 0.012). The median time-to-onset was 8.0 (3.0-13.0) days for those aged <60 years and 12.0 (7.0-24.5) days for those aged >/=60 years (log-rank p < 0.001). CONCLUSIONS: Older age was associated with longer reported time-to-onset of EM, suggesting age-related differences in reported EM onset patterns in a spontaneous reporting database. |
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| ジャーナル名 | Cureus |
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| Pubmed追加日 | 2026/9/6 |
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| 投稿者 | Tanaka, Hideyuki; Nakao, Satoshi; Sugishita, Kana; Yamazaki, Tomofumi; Ito, Seiichiro; Kageyama, Koichi; Sato, Mugita; Ino, Yoko; Iguchi, Kazuhiro; Nakamura, Mitsuhiro |
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| 組織名 | Laboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, JPN.;Laboratory of Pharmaceutical Health Care and Promotion, Gifu Pharmaceutical;University, Gifu, JPN.;Laboratory of Community Pharmacy, Gifu Pharmaceutical University, Gifu, JPN. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42701639/ |
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