| アブストラクト | This systematic review and meta-analysis of cohort studies aimed to synthesize existing evidence on the joint association of physical activity (PA) and sedentary behaviour (SB) with cardiovascular disease (CVD) risk among adults. We searched PubMed, EMBASE, and Cochrane for English studies published between January 2010 and February 2025 that examined the joint association of PA and SB (fatal and non-fatal) CVD among adults and pooled their results through meta-analyses using study-level data. Using findings from 17 studies, the pooled effect size for the lowest PA + highest SB group was 1.78 (95% CI: 1.59-2.00), suggesting increased risk for CVD compared with the reference group (i.e. highest PA + lowest SB). Compared with the same reference group, we found an increased risk for CVD in the lowest PA + lowest SB (HR = 1.25, 95% CI: 1.12-1.40) and the highest PA + highest SB (HR = 1.16, 95% CI: 1.06-1.27) groups. Subgroup analyses according to domains or types of PA and SB exposure, outcome measures, and exposure measurement method revealed a similar pattern. In conclusion, individuals with the lowest PA combined with the highest SB may experience an increased risk for CVD events compared with those with the highest PA and lowest SB. There was also an increased risk for individuals with a combination of either low PA + low SB and high PA + high SB, albeit to a lesser extent. Although substantial study-level heterogeneity exists, the results highlight the potential value of considering both behaviours jointly in relation to CVD risk. |
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| ジャーナル名 | European journal of preventive cardiology |
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| Pubmed追加日 | 2026/5/12 |
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| 投稿者 | Lunar, Frances Rom; Du, Zhen; Amagasa, Shiho; Kondo, Naoki; Inoue, Kosuke |
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| 組織名 | Department of Social Epidemiology, School of Public Health and Graduate School of;Medicine, Kyoto University, Kyoto 606-8501, Japan.;JBI Evidence-Based Nursing and Midwifery PR China, Southern Medical University,;Guangzhou 510515, China.;Graduate School of Public Health, Teikyo University, Tokyo 173-8605, Japan.;Department of Preventive Medicine and Public Health, Tokyo Medical University,;Tokyo 160-8402, Japan.;Department of Health Promotion and Behavioral Sciences, School of Public Health;and Graduate School of Medicine, Kyoto University, Yoshida-Konoecho, Sakyo-ku,;Kyoto-shi, Kyoto 606-8501, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42116645/ |
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