論文・技術情報追加のお知らせ

①Systematic Analysis of Protein Targets Associated with Adverse Events of Drugs from Clinical Trials and Postmarketing Reports.

臨床試験及び製造販売後有害事象報告システムを活用した有害事象関連タンパク質ターゲットの解析研究

対象DB：FAERS

②Comparison of contraceptive failures associated with CYP3A4-inducing drug-drug interactions by route of hormonal contraceptive in an adverse event reporting system.

CYP3A4誘発薬とレボノルゲストレルおよびエトノゲストレル/デソゲストレルの投与経路、併用による意図しない妊娠転帰比較研究

対象DB：FAERS

③Comprehensive Study of the Risk Factors for Medication-Related Osteonecrosis of the Jaw Based on the Japanese Adverse Drug Event Report Database.

JADERを用いた薬剤関連顎骨壊死症のリスク因子の包括的検討研究

対象DB：JADER

④PCSK9 Inhibitors and Neurocognitive Adverse Drug Reactions: Analysis of Individual Case Safety Reports from the Eudravigilance Database.

PCSK9阻害薬と神経認知有害薬物反応の個別症例安全性報告の分析

対象DB：EudraVigilance

⑤We Really Need Clear Guidelines and Recommendations for Safer and Proper Use of Aripiprazole and Risperidone in a Pediatric Population: Real-World Analysis of EudraVigilance Database.

小児集団に関連するアリピプラゾールとリスペリドンの個別症例安全性報告書を対象とした記述的分析研究

対象DB：EudraVigilance

⑥Myelodysplastic syndrome and acute myeloid leukaemia in patients treated with PARP inhibitors: a safety meta-analysis of randomised controlled trials and a retrospective study of the WHO pharmacovigilance database.

PARP阻害薬に関連する骨髄異形成症候群及び急性骨髄性白血病のファーマコビジランス研究

対象DB：VigiBase

⑦Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data.

育児期の女性におけるトラネキサム酸に関連した腎虚血性有害事象のファーマコビジランス研究

対象DB：VigiBase

⑧Remdesivir and acute renal failure: a potential safety signal from disproportionality analysis of the WHO safety database.

レムデシビルと急性腎不全の安全性シグナル解析研究

対象DB：VigiBase

⑨Serial Changes in Clinical Presentations and Outcomes of 5,740 Patients Requiring Repeated Hospital Admissions (Four or More Times) due to Worsened Heart Failure.

心不全の悪化による4回以上入院を要した臨床症状や転帰に関する調査研究

対象DB：DPC

⑩Quantifying the impact of pre-existing conditions on the stage of oesophagogastric cancer at diagnosis: a primary care cohort study using electronic medical records.

食道胃がんの病期と既往症との関連性調査研究

対象DB：CPRD