論文・技術情報追加のお知らせ

1. PARP inhibitor-related acute renal failure: a real-world study based on the FDA adverse event reporting system database.

FAERSを用いた研究で、PARP阻害剤と急性腎障害の関連が明らかに

対象DB：FAERS

2. Compartment syndrome associations with drugs: a pharmacovigilance study of the FDA adverse event reporting system (FAERS).

FAERSを用いた研究で、特定の薬剤が筋室症候群と関連している可能性

対象DB：FAERS

3. Exploring the Relationship Between Atorvastatin and Memory Loss: A Comprehensive Analysis Integrating Real-World Pharmacovigilance and Mendelian Randomization.

アトルバスタチンは記憶喪失の副作用と関連あり

対象DB：FAERS

4. Analysis of hemorrhagic drug-drug interactions between P-gp inhibitors and direct oral anticoagulants from the FDA adverse event reporting system.

P-gp阻害剤と経口抗凝固薬の併用は出血リスクを増加させる可能性

対象DB：FAERS

5. Hepatic injury and hepatic failure adverse events in 3,4-methylenedioxymethamphetamine users reported to the FDA Adverse Event Reporting System.

MDMAの肝障害リスクを調査

対象DB：FAERS

6. Risk of stress cardiomyopathy associated with selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors: a real-world pharmacovigilance analysis.

SSRI/SNRIは中年女性にストレス心筋症のリスク増

対象DB：FAERS

7. Association of thrombocytopenia with immune checkpoint inhibitors: a large-scale pharmacovigilance analysis based on the data from FDA adverse event reporting system database.

ICIs治療でITPのリスク増、60日以内に発症要警戒

対象DB：FAERS

8. Sodium-glucose cotransporter-2 inhibitors and abnormal serum potassium: a real-world, pharmacovigilance study.

SGLT2iは他の糖尿病薬より高カリウム血症と低カリウム血症の報告が少ない

対象DB：FAERS

9. Comparison of Infection Risks Between Various Inhaled and Intranasal Corticosteroids: A Pharmacovigilance Analysis Based on the FAERS Database.

ICSとINCsは女性に感染リスクが高く、フルチカゾンは肺炎、モメタゾンは上気道感染が多い

対象DB：FAERS

10. Hepatitis-related adverse events associated with immune checkpoint inhibitors in cancer patients: an observational, retrospective, pharmacovigilance study using the FAERS database.

免疫チェックポイント阻害薬は重篤な肝炎関連有害事象のリスクが高い

対象DB：FAERS

11. Capecitabine-associated gastrointestinal ulceration, haemorrhage, and obstruction: a pharmacovigilance analysis based on the FAERS.

カペシタビンは、消化管潰瘍、出血、閉塞リスクを増加させる可能性

対象DB：FAERS

12. Risk of immune system and skin and subcutaneous tissue related adverse events associated with oxaliplatin combined with immune checkpoint inhibitors: a pharmacovigilance study.

オキサリプラチンと免疫チェックポイント阻害剤の併用は、発疹リスクを増加させる可能性あり

対象DB：FAERS

13. Pharmacovigilance of esketamine nasal spray: an analysis of the FDA adverse event reporting system database.

エスケタミン鼻スプレーの有害事象をFAERSデータから解析

対象DB：FAERS

14. Comparative analysis of adverse events among intravesical drugs in bladder cancer: a real-world study on FAERS database.

膀胱内療法薬の有害事象を解析し、安全性プロファイルを解明

対象DB：FAERS

15. Dermatologic adverse events associated with chimeric antigen receptor T-cell therapy: a pharmacovigilance analysis of the FDA reporting system.

CAR-T療法で重篤な皮膚有害事象の報告率が増加し、高い死亡率と関連

対象DB：FAERS

16. Cutaneous T-cell lymphoma following dupilumab use - A real-world pharmacovigilance study of the FDA adverse event reporting system (FAERS).

FAERSを用いたデュピルマブ使用後の皮膚T細胞性リンパ腫に関する研究

対象DB：FAERS

17. Safety evaluation of bempedoic acid: A pharmacovigilance analysis using FDA adverse event reporting system data.

ベンペド酸の副作用データマイニング研究

対象DB：FAERS

18. Recommendations for the selection of nucleoside analogues as antihuman herpesvirus drugs: a real-world analysis of reported cases from the FDA adverse event reporting system.

抗ヘルペスウイルス薬の副作用をFAERSから分析、治療プロトコルの改善と個別化戦略の開発

対象DB：FAERS

19. Antidepressants and fetal death: A systematic review and disproportionality analysis in the WHO safety database (VigiBaseⓇ).

抗うつ薬の胎児への曝露が特に妊娠初期において胎児死亡と関連

対象DB：VigiBase

20. PCSK9 Inhibitors and Infection-Related Adverse Events: A Pharmacovigilance Study Using the World Health Organization VigiBase.

PCSK9阻害剤と感染症の有害事象の関連を観察的な薬剤動態学研究で検討

対象DB：VigiBase

21. Identification of Drugs and Patient Profiles at Risk for Severe Skin Injuries Due to Extravasation: Analysis of a Spontaneous Reporting System.

皮膚重篤な損傷のリスク要因の特定と組み合わせの分析

対象DB：JADER

22. Comparison of embolic risk in left ventricular thrombus between nonischemic and ischemic cardiomyopathy: A nationwide database analysis.

JROAD-DPCデータベースからのLV血栓患者の解析

対象DB：DPC

23. Perioperative complications and cost of posterior decompression with fusion in thoracic spine for ossification of the posterior longitudinal ligament and ossification of the ligamentum flavum -a comparative study using a national inpatient database.

PDFにおけるT-OPLLとT-OLFの手術における周術期合併症の違いを検討

対象DB：DPC

24. Propofol infusion syndrome (PRIS) incidence and related symptoms in children: a retrospective analysis of a nationwide hospital-based database in Japan.

小児におけるプロポフォール静脈投与症候群の発生と関連症状の後ろ向き分析

対象DB：DPC

25. Does total hip arthroplasty in elderly patients with femoral neck fractures reduce complications?: A Japanese DPC study.

日本の高齢者における大腿骨頚部骨折でのTHAとBHAの比較研究

対象DB：DPC

26. Is the increase in the number of total hip arthroplasties in Japan due to an aging society?

日本における全股関節置換術の数は増加しており、特に高齢者での実施が顕著

対象DB：NDB

27. Clinical Outcomes in Patients with CKD and Rapid or Non-rapid eGFR Decline: A Report from the DISCOVER CKD Retrospective Cohort.

CKD患者の急速なeGFR低下は悪化リスクを増加

対象DB：CPRD,MDV

28. Real-world evidence of systemic treatment practices for biliary tract cancer in Japan: Results of a database study.

日本の胆道癌治療は単剤療法が多く、感染管理が課題

対象DB：MDV

29. The effects of the first UK lockdown for the COVID-19 pandemic on primary-care-recorded cancer and type-2 diabetes mellitus records: A population-based quasi-experimental time series study.

COVID-19でがん・糖尿病診断が減少し遅延

対象DB：CPRD

30. Association between socioeconomic deprivation, ethnicity and health outcomes in preschool children with recurrent wheeze in England: a retrospective cohort study.

喘鳴/喘息の治療には社会的・人種的格差がある

対象DB：CPRD

31. Using Routinely Collected Electronic Healthcare Record Data to Investigate Fibrotic Multimorbidity in England.

線維症の多疾患併存は16人に1人の割合

対象DB：CPRD

32. Incretin-based therapy and the risk of diabetic foot ulcers and related events.

インクレチン療法は糖尿病足潰瘍リスクを低減

対象DB：CPRD

33. Estimating the healthcare burden of Prurigo Nodularis in England: a CPRD database study.

中等度から重度の瘙痒性結節症は高い医療資源が必要

対象DB：CPRD

34. Safety-netting advice documentation out-of-hours: a retrospective cohort from 2013 to 2020.

時間外診療での安全確認アドバイス（SNA）頻度は78%、精神疾患は電話相談が主で改善が必要

対象DB：GPRD