論文・技術情報追加のお知らせ

1. Drug-induced nephrolithiasis: a real-world pharmacovigilance study of the FDA Adverse Event Reporting System.

薬剤誘発性腎結石のリスクが多くの薬剤で確認され、臨床での注意が必要

対象DB：FAERS

2. Detection of risk signals for ustekinumab in the real world using the FDA Adverse Event Reporting System (FAERS).

ウステキヌマブ使用で有害事象リスク、特に扁平上皮癌や膿瘍、瘻孔に注意が必要

対象DB：FAERS

3. Risk of congenital anomalies associated with psychotropic medications: a review of neonatal reports in the FDA adverse event reporting System (FAERS).

妊娠中の向精神薬使用で新生児の先天異常リスク増、特に心臓や神経系に注意

対象DB：FAERS

4. Concomitant use of sodium-glucose co-transporter 2 inhibitors and metformin and the risk of osteomyelitis reporting: a disproportionality analysis based on FAERS database.

SGLT2阻害薬で骨髄炎リスク増、特にカナグリフロジン関連

対象DB：FAERS

5. Drug-Associated Risk of Subacute Cutaneous Lupus Erythematosus: A Pharmacovigilance Study of the FDA Adverse Event Reporting System.

薬剤関連亜急性皮膚エリテマトーデスのリスクを調査

対象DB：FAERS

6. Adverse event of ruxolitinib cream: a real-world analysis based on FDA Adverse Event Reporting System from 2021 to 2024.

ルキソリチニブクリームで皮膚障害やアクネなどの副作用が報告

対象DB：FAERS

7. A real-world pharmacovigilance analysis for agalsidase beta: findings from the FDA adverse event reporting database.

アガルシダーゼβで男性特有の副作用リスクが判明

対象DB：FAERS

8. Disproportionality Analysis of Hepatotoxic and Gastrointestinal Adverse Events Associated With Nintedanib Using the Japanese Adverse Drug Event Report (JADER) Database.

ニンテダニブの副作用は3～4ヶ月以内に発生し、適切な管理が必要

対象DB：JADER

9. Evaluation of Times-to-onset and Outcomes of Lung Adverse Events Associated With Sorafenib Using JADER.

ソラフェニブ治療中の肺有害事象は重篤で継続的モニタリングが重要

対象DB：JADER

10. Anamorelin and Conduction Defects: A Literature Review and Analysis of the Japanese Pharmacovigilance Database.

アナモレリンの安全性評価で、服用後2～3週間に心伝導障害のリスク増加が確認

対象DB：JADER

11. Development of a Drug Safety Signal Detection Reference Set Using Japanese Safety Information.

日本の薬剤安全情報を基にした参照セットを開発し、データマイニング手法の評価に活用

対象DB：JADER

12. Reversible cerebral vasoconstriction syndrome in a methylphenidate-treated patient: a case report.

メチルフェニデートはまれにRCVSを引き起こす可能性があり、臨床医は注意が必要

対象DB：FPVD,VigiBase

13. Automated redaction of names in adverse event reports using transformer-based neural networks.

自動名詞削除法は有害事象報告で高い再現率を示し、患者の機密性をほぼ保持しつつ臨床的有用性を維持可能

対象DB：VigiBase

14. Evaluation of Lung Adverse Events Associated With Lenvatinib: A Post-marketing Surveillance Study.

レンバチニブの肺有害事象、特に気管瘻・気管出血は重大な転帰を持ち、投与期間全体で監視が必要

対象DB：JADER

15. Suicide attempt and self-harm among hospitalized children in Japan: A nationwide inpatient database study.

子どもの自殺企図・自傷は性別・年齢で差異。対策が必要

対象DB：DPC

16. Exploring the impact of perioperative analgesia on postoperative chronic analgesic prescriptions in patients with lung cancer undergoing minimally invasive thoracic surgery: A retrospective observational study.

肺癌MITSの術後鎮痛剤処方率は麻酔法で差なし

対象DB：DPC

17. Updated information on the Diagnosis Procedure Combination data.

DPCデータは多領域で活用可能な詳細な医療情報を提供

対象DB：DPC

18. Impact of COVID-19 on hospital visit behaviour in cancer patients in Japan: a nationwide study.

COVID-19後、がん患者の遠隔病院受診が減少

対象DB：DPC

19. Impact of COVID-19 pandemic on pneumonia trends in Japan: Insights from diagnosis procedure combination data.

COVID-19後、日本で非誤嚥性肺炎が大幅減少、誤嚥性肺炎は微減

対象DB：DPC

20. Association of the Glasgow Coma Scale with the Length of Hospital Stay in Patients with Thyroid Storm.

GCSは甲状腺クリーゼ患者の入院期間指標に有用

対象DB：DPC

21. Seasonal trends of pyogenic spondylodiscitis in Japan: a nationwide inpatient database study.

化膿性脊椎炎は季節で流行変動、MRSAは季節差なし

対象DB：DPC

22. Association between polypharmacy and the long-term prescription of hypnotics in Japan: a retrospective cross-sectional study.

睡眠薬多剤併用は長期処方と強く関連

対象DB：JMDC

23. The Long-Term Cost-Effectiveness of Tirzepatide 5 mg versus Dulaglutide 0.75 mg for the Treatment of People with Type 2 Diabetes in Japan.

チルゼパチド5mgはコスト効果が高い糖尿病治療薬

対象DB：JMDC

24. Analysis of recent changes in treatment options for patients with hepatocellular carcinoma using data from a highly comprehensive Japanese national database: Impact of advances in systemic therapy and minimally invasive surgery.

肝癌治療で全身療法と腹腔鏡手術が増加傾向

対象DB：NDB

25. Impact of Coronavirus Disease 2019 Emergency Declarations on Surgeries for Deep Neck Infection Incidence in Japan.

COVID-19対策で深頸部感染症手術が減少

対象DB：NDB

26. Seasonal variations and environmental influences on dry eye operations in Japan.

ドライアイ手術は冬に多く湿度と気温が影響

対象DB：NDB

27. Utilization and regional disparities of radiotherapy in cancer treatment in Japan: a longitudinal study using NDB open data.

日本の高精度放射線治療利用率は増加し地域格差は縮小傾向

対象DB：NDB

28. School-Based Fluoride Mouth-Rinse Programs and Dental Caries Treatment Expenditure: An Ecological Study of the NDB Open Data Japan.

学校でのフッ化物洗口は虫歯治療費を削減し費用対効果が高い

対象DB：NDB

29. Treatment pattern and clinical outcomes of remdesivir in hospitalized COVID-19 patients with severe chronic kidney disease: a database analysis of acute care hospitals in Japan.

重度CKD患者のCOVID-19入院でRDV治療後、28日以内に72%が回復

対象DB：MDV

30. Estimating undiagnosed dementia in England using capture recapture techniques.

認知症診断率は1997年42%から2018年84%に改善

対象DB：CPRD

31. Gestational diabetes mellitus and subsequent cardiovascular disease in a period of rising diagnoses: Cohort study.

妊娠糖尿病は心血管疾患リスクを約2倍に増加

対象DB：CPRD

32. Psoriasis and dementia: A population-based matched cohort study of adults in England.

乾癬は血管性認知症リスクをわずかに増加させる可能性

対象DB：CPRD

33. Incidence trends in ischaemic and non-ischaemic heart failure in people with and without type 2 diabetes, 2000-2019: An observational study in England.

2型糖尿病では非虚血性心不全リスクが依然高く、対策が必要

対象DB：CPRD

34. Maternal and pregnancy factors contributing to the association between area deprivation and infant mortality in England: a retrospective cohort study.

乳児死亡の格差要因は早産、喫煙、若年出産、抑うつ

対象DB：CPRD

35. Inhaled corticosteroids and major cardiovascular events in people with chronic obstructive pulmonary disease.

ICSはMACEを減少させず、心不全のみ軽減の可能性

対象DB：CPRD

36. Risk of mortality between warfarin and direct oral anticoagulants: population-based cohort studies.

ワルファリンの死亡リスクはTTRに依存しDOACと差異

対象DB：CPRD

37. Cardiovascular events in patients with gout initiating urate-lowering therapy with or without colchicine for flare prophylaxis: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data.

コルヒチン併用で尿酸降下療法中の心血管リスクが低下

対象DB：CPRD

38. Safety and efficacy of intrathecal antibodies to Nogo-A in patients with acute cervical spinal cord injury: a randomised, double-blind, multicentre, placebo-controlled, phase 2b trial.

急性脊髄損傷患者でNG101の効果は確認されず、追加研究が必要

対象DB：CVAR

39. Lifelog Data Suggest Decreased Physical Activity Across Cancer Diagnosis and Treatment: Analysis Using Smartphone Step Count Data Linked to a Japanese Claims Database.

がん診断・治療で活動量が減少し、診断前から低下傾向が示唆

対象DB：DeSC