論文・技術情報追加のお知らせ

1. Pharmacovigilance analysis of glycoprotein IIb/IIIa inhibitors: A FAERS-based signal detection study.

FAERSを用いた糖タンパク質IIb/IIIa阻害薬3種の安全性比較。

対象DB：FAERS

2. Potential heterogeneity of epcoritamab associated adverse events in demographics and dosing regimens.

エプコリタマブ副作用の人口統計・用量別における多様性解析。

対象DB：FAERS,JADER

3. Association Between Dextromethorphan/Bupropion with Diabetes Mellitus and Hyperglycemia: Reports to the Food and Drug Administration Adverse Event Reporting System (FAERS).

デキストロメトルファン/ブプロピオンによる糖尿病等の報告調査。

対象DB：FAERS

4. Comparative safety signals of carboplatin and cisplatin in lung cancer: a pharmacovigilance study based on FAERS.

肺がんにおけるカルボプラチンとシスプラチンの副作用比較解析。

対象DB：FAERS

5. Real-world safety profile of mitotane in adrenocortical carcinoma: a retrospective cross-sectional study integrating pharmacovigilance and interpretable machine learning.

副腎皮質がん治療薬ミトタンのリアルワールド安全性評価。

対象DB：FAERS

6. Comparative safety profiles of antibody-drug conjugates: a real-world analysis of monotherapy and combination regimens in solid tumors.

抗体薬物複合体（ADC）の安全性プロファイルに関する比較解析。

対象DB：FAERS

7. Development and validation of a MedDRA-based signal detection construct for drug-induced neurobehavioral impairment.

運転能力影響薬の不均衡分析のためのMedDRAシグナル検出手法。

対象DB：FAERS

8. Heart failure reporting signals associated with concomitant mavacamten and CYP inhibitors in obstructive hypertrophic cardiomyopathy: a real-world pharmacovigilance study with propensity score matching.

マバカムテンとCYP阻害薬の併用における心不全シグナルの解析。

対象DB：FAERS

9. FAERS database reveals latent signals of neuro-ophthalmic toxicity associated with immune checkpoint inhibitors: feature mining and clinical warnings.

FAERSに基づく免疫チェックポイント阻害薬の神経眼毒性解析。

対象DB：FAERS

10. The Real-World Safety Profile of Hydroxyprogesterone: A Pharmacovigilance Study Based on the Food and Drug Administration's Adverse Event Reporting System Database.

ヒドロキシプロゲステロンの市販後安全性プロファイルに関する調査。

対象DB：FAERS

11. FAERS-based pharmacovigilance and network toxicology analysis of esomeprazole-associated osteoporosis.

エソメプラゾール誘発性骨粗鬆症の不均衡分析とネットワーク毒性学。

対象DB：FAERS

12. Comparative pharmacovigilance of Levodopa and Pramipexole: a disproportionality analysis of the FAERS database.

レボドパとプラミペキソールの安全性プロファイル比較評価。

対象DB：FAERS

13. Sex-Specific Safety Profiles of PI3K Inhibitors: A Real-World Pharmacovigilance Study Based on FAERS Database.

PI3K阻害薬の副作用報告における性別差のリアルワールド解析。

対象DB：FAERS

14. A clinical decision support system for predicting drug-related adverse effects in pediatric patients with congenital heart disease: Development and retrospective evaluation.

先天性心疾患小児における薬剤副作用予測のための決定支援システム。

対象DB：FAERS

15. Real-world pharmacovigilance analysis and mechanistic exploration of JAK inhibitor-associated skin tumor adverse events using FAERS, VigiBase, and network pharmacology.

JAK阻害薬関連認知症のリアルワールド解析と機序解明の試み。

対象DB：VigiBase

16. Seizures associated with clozapine augmentation by other antipsychotics: a pharmacovigilance-pharmacodynamic analysis using VigiBase.

クロザピンへの他抗精神病薬追加に伴う痙攣リスクの不均衡分析。

対象DB：VigiBase

17. Drug-induced dysphagia: Analysis of age and time of onset profiles using a Japanese pharmacovigilance database.

JADERデータを用いた薬剤性嚥下障害の発症時期と年齢層の解析。

対象DB：JADER

18. Early rehabilitation initiation after aneurysmal subarachnoid haemorrhage: evaluation of mortality and functional outcomes.

くも膜下出血後の早期リハビリ開始時期と複合転帰の関連性評価。

対象DB：DPC

19. Five-Year Trends in Biomarker Testing and Targeted Therapy for NSCLC: A Patient-Initiated Nationwide Survey in Japan.

非小細胞肺がんにおけるバイオマーカー検査と分子標的薬の動向。

対象DB：DPC

20. Association Between In-Hospital Mortality and ICU Patient Volume at the Facility-Level Stratified by Severity.

重症患者数と院内死亡率の関連性に関する施設レベルの検証。

対象DB：DPC,DeSC

21. Effectiveness of Blood Perfusion Assessment by Indocyanine Green Fluorescence Angiography in the Prevention of Anastomotic Leakage after Rectal Cancer Surgery in Japan: A Retrospective Study Using the Diagnosis Procedure Combination Database.

大腸切除術におけるICG蛍光血管造影の縫合不全軽減効果の検証。

対象DB：DPC

22. Adult T-cell Leukemia/Lymphoma in Japan: Real-World Treatment Patterns, Healthcare Resource Utilization, and Costs.

日本における成人T細胞白血病リンパ腫の治療パターンと医療費。

対象DB：MDV

23. Treatment Persistence of Interleukin-17 Inhibitors and Factors Associated with Persistence in Patients with Psoriasis Vulgaris in Japan: Retrospective Database Study.

乾癬におけるIL-17阻害薬の治療継続性と継続関連因子の解析。

対象DB：MDV

24. Medication use during pregnancy and pregnancy outcomes in women with immune mediated inflammatory diseases: a UK-based matched cohort study.

免疫多様性炎症性疾患女性における妊娠中服薬と妊娠転帰の調査。

対象DB：CPRD

25. Time to Insulin Initiation Among Patients With Type 2 Diabetes Treated With Second-Line Antidiabetic Drugs.

2型糖尿病患者における二次治療後のインスリン導入時期の検討。

対象DB：CPRD

26. Glucocorticoid exposure and initiation of SSRIs among patients with rheumatoid arthritis: A nested case-control study in UK primary care.

関節リウマチ患者のステロイド使用とSSRI開始リスクの解析。

対象DB：CPRD

27. Risk factors and coronary events: attenuation of the association in secondary prevention.

冠動脈疾患サバイバーにおける二次予防での危険因子の減弱効果。

対象DB：CPRD

28. Obesity Subphenotypes in Atrial Fibrillation: A Linked Electronic Health Record Study in the United Kingdom.

心房細動患者における肥満サブフェノタイプと臨床転帰の関連。

対象DB：CPRD

29. Atopic dermatitis is associated with herpes zoster in adults - A matched cohort study using electronic health records data in England.

成人アトピー性皮膚炎における帯状疱疹発症リスクのコホート研究。

対象DB：CPRD

30. Incidence, Characteristics, and Management Pathways of Obstructive Sleep Apnea in England: A 10-Year Retrospective Cohort Study.

英国における閉塞性睡眠時無呼吸症候群の疫学と管理経路の調査。

対象DB：CPRD

31. External Validation of SELECT Trial-Derived Cardiovascular Risk Equations in a UK Population with Overweight or Obesity and Established Cardiovascular Disease Without Diabetes.

SELECT試験心血管リスク予測式の英国コホート外部検証。

対象DB：CPRD

32. Predicting deep venous thrombosis and pulmonary embolism in community patients with superficial venous thrombosis: a model development study.

表在性血栓性静脈炎患者における深部静脈血栓症リスク予測モデル。

対象DB：CPRD

33. Real-world osteoporosis management before and after sustaining fragility fractures in Japanese older adults aged >/= 75 years: Japanese bone-fracture osteoporosis in late-stage population database (J-BOLD) study.

脆弱性骨折前後の骨粗鬆症管理の実態に関する大規模コホート調査。

対象DB：DeSC

34. Evaluation of an EAST Nudge-Based Oral Health Promotion Leaflet for Workers: A Six-Month Randomized Controlled Trial.

ナッジ理論に基づく従業員向け歯科検診啓発リーフレットの評価。

対象DB：DeSC