| アブストラクト | The numbers of cases and deaths from coronavirus disease 2019 (COVID-19) are continuously increasing. Many people are concerned about the efficacy and safety of the COVID-19 vaccines. We performed a comprehensive analysis of the published trials of COVID-19 vaccines and the real-world data from the Vaccine Adverse Event Reporting System. Globally, our research found that the efficacy of all vaccines exceeded 70%, and RNA-based vaccines had the highest efficacy of 94.29%; moreover, Black or African American people, young people, and males may experience greater vaccine efficacy. The spectrum of vaccine-related adverse drug reactions (ADRs) is extremely broad, and the most frequent ADRs are pain, fatigue, and headache. Most ADRs are tolerable and are mainly grade 1 or 2 in severity. Some severe ADRs have been identified (thromboembolic events, 21-75 cases per million doses; myocarditis/pericarditis, 2-3 cases per million doses). In summary, vaccines are a powerful tool that can be used to control the COVID-19 pandemic, with high efficacy and tolerable ADRs. In addition, the spectrum of ADRs associated with the vaccines is broad, and most of the reactions appear within a week, although some may be delayed. Therefore, ADRs after vaccination need to be identified and addressed in a timely manner. |
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| ジャーナル名 | Molecular therapy : the journal of the American Society of Gene Therapy |
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| 投稿日 | 2021/8/9 |
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| 投稿者 | Cai, Changjing; Peng, Yinghui; Shen, Edward; Huang, Qiaoqiao; Chen, Yihong; Liu, Ping; Guo, Cao; Feng, Ziyang; Gao, Le; Zhang, Xiangyang; Gao, Yan; Liu, Yihan; Han, Ying; Zeng, Shan; Shen, Hong |
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| 組織名 | Department of Oncology, Xiangya Hospital, Central South University, Changsha,;Hunan 410008, China; Key Laboratory for Molecular Radiation Oncology of Hunan;Province, Xiangya Hospital, Central South University, Changsha, Hunan 410008,;China.;Department of Life Science, McMaster University, Hamilton, ON L8S 4L8, Canada.;China; Department of Pathology, University of Pittsburgh School of Medicine,;Pittsburgh, PA, 15213, USA. Electronic address: yinghan@csu.edu.cn.;China; National Clinical Research Center for Geriatric Disorders, Xiangya;Hospital, Central South University, Changsha, Hunan 410008, P.R. China.;Electronic address: zengshan2000@csu.edu.cn.;Electronic address: hongshen2000@csu.edu.cn. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34365034/ |
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