| アブストラクト | Direct oral anticoagulant drugs (DOACs) interfere with the coagulation process, thus improving patient care for those who require anticoagulant treatment. This study presents a descriptive analysis of adverse reactions (ADRs) attributed to DOAC dosage errors (overdose, underdose, and improper dose). The analysis was performed based on the Individual Case Safety Reports from the EudraVigilance (EV) database. Results show that data reported for rivaroxaban, apixaban, edoxaban, and dabigatran are mostly regarding underdosing (51.56%) compared to overdosing (18.54%). The most dosage error reports were identified for rivaroxaban (54.02%), followed by apixaban (33.61%). Dabigatran and edoxaban had similar percentages (6.26% and 6.11%, respectively) regarding dosage error reports. Since coagulation issues can become life-threatening events, and factors such as advanced age and renal failure can influence the pharmacokinetics of drugs, the correct usage of DOACs is of utmost importance for the management and prevention of venous thromboembolism. Thus, the collaboration and the complementarity of knowledge of physicians and pharmacists may offer a reliable solution for DOAC dose management and improve patient care. |
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| ジャーナル名 | Pharmaceuticals (Basel, Switzerland) |
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| 投稿日 | 2023/3/30 |
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| 投稿者 | Morgovan, Claudiu; Dobrea, Carmen Maximiliana; Chis, Adriana Aurelia; Juncan, Anca Maria; Arseniu, Anca Maria; Rus, Luca Liviu; Gligor, Felicia Gabriela; Ardelean, Simona Alexandrina; Stoicescu, Laurentiu; Ghibu, Steliana; Frum, Adina |
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| 組織名 | Preclinical Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu,;550169 Sibiu, Romania.;Department of Pharmaceutical Sciences, Faculty of Pharmacy, "Vasile Goldis";Western University of Arad, 310025 Arad, Romania.;Department of Cardiology, Vth Medical Clinic, Faculty of Medicine, "Iuliu;Hatieganu" University of Medicine and Pharmacy, 400139 Cluj-Napoca, Romania.;Department of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy,;"Iuliu Hatieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca,;Romania. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36986554/ |
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