| アブストラクト | OBJECTIVE: Immune checkpoint inhibitors (ICIs) combined with platinum-based compounds are commonly used in the treatment of certain malignant tumors. This study aims to analyze adverse events (AEs) associated with the combination therapy of ICIs and platinum-based compounds by using the FAERS database. METHODS: This study retrieved relevant adverse event (AE) data from the FAERS database (2008-2024) and conducted a retrospective analysis of the collected AEs. Multiple disproportionality analysis algorithms were employed, including the Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-item Gamma Poisson Shrinker (MGPS). RESULTS: Analysis of 28,585 reports identified 27 significant SOC-level signals, strongest for hematological (ROR = 6.3), endocrine (ROR = 14.3), and hepatobiliary disorders (ROR = 4.49). Key PTs included malignant neoplasm progression (ROR = 16), febrile neutropenia (ROR = 15.31), and myocarditis (ROR = 16.3). 45.5% of AEs occurred within 1 month (median onset: 38 days). Combination therapy showed lower rates vs. monotherapy for malignancy progression and nephrotoxicity, but higher neurotoxicity (628 neuropathy cases). CONCLUSION: The combination exhibits distinct early-onset toxicities (early-onset hematological/endocrine/hepatic) and novel risks (neuropathy/myocarditis/leukemia), necessitating enhanced initial monitoring and subgroup-specific management. |
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| ジャーナル名 | Cancer medicine |
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| Pubmed追加日 | 2026/3/31 |
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| 投稿者 | Liu, Boyi; Zhang, Wenchao; Huang, Ruizhe; Liu, Dinwen; Liu, Jiaxing; Han, Ao; Li, Yike; Chen, Danna |
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| 組織名 | The First Clinical College, Changsha Medical University, Changsha, China.;Institute of Cytology and Genetics, Basic Medical School, University of South;China, Hengyang, China.;Changsha Hospital for Maternal & Child Health Care, Changsha, China.;Department of Basic Medical Sciences, Changsha Medical University, Changsha,;Hunan, China.;Hunan Provincial University Key Laboratory of the Fundamental and Clinical;Research on Functional Nucleic Acid, Changsha, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41912473/ |
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