| アブストラクト | Drug-drug interactions (DDIs) are one of the indispensable factors leading to adverse event reactions. Considering the unique structure of AERS (Food and Drug Administration Adverse Event Reporting System (FDA AERS)) reports, we changed the scope of the window value in the original skip-gram algorithm, then propose a language concept representation model and extract features of drug name and reaction information from large-scale AERS reports. The validation of our scheme was tested and verified by comparing with vectors originated from the cooccurrence matrix in tenfold cross-validation. In the verification of description enrichment of the DrugBank DDI database, accuracy was calculated for measurement. The average area under the receiver operating characteristic curve of logistic regression classifiers based on the proposed language model is 6% higher than that of the cooccurrence matrix. At the same time, the average accuracy in five severe adverse event classes is 88%. These results indicate that our language model can be useful for extracting drug and reaction features from large-scale AERS reports. |
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| ジャーナル名 | Computational and mathematical methods in medicine |
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| 投稿日 | 2020/5/1 |
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| 投稿者 | Wang, Li; Pan, Wenjie; Wang, QingHua; Bai, Heming; Liu, Wei; Jiang, Lei; Zhang, Yuanpeng |
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| 組織名 | Department of Medical Informatics, Medical School, Nantong University, Nantong;226001, China.;Research Center for Intelligence Information Technology, Nantong University,;Nantong 226001, China.;Department of Rheumatology and Immunology, Changzheng Hospital, The Second;Military Medical University, Shanghai 200433, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32351611/ |
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