| アブストラクト | BACKGROUND: Proton pump inhibitors (PPIs) are effective treatments for acid-related disorders but may pose tumor risks with long-term use. Current research on PPI-associated tumor adverse events (TAEs) is limited and inconclusive. This study aims to comprehensively analyze the relationship between PPIs and TAEs. METHODS: We analyzed PPI adverse reaction reports from the FDA Adverse Event Reporting System (FAERS) database spanning from 2004 to 2024, focusing on five commonly used PPIs: esomeprazole, pantoprazole, lansoprazole, omeprazole, and rabeprazole. We conducted a disproportionality analysis utilizing the Reporting Odds Ratio (ROR) to identify potential TAEs associated with PPIs. We conducted univariate logistic regression analysis to explore the influencing factors. RESULTS: A total of 3,133 TAEs were identified, representing 2.36% of all PPI-related adverse events (AEs). The most common TAEs were gastric cancer (19.05%) and malignant neoplasm (7.23%). Disproportionality analysis revealed ten significant TAEs associated with PPIs, including gastric adenocarcinoma and renal cell carcinoma. The median age of those reporting TAEs was 59 (interquartile range [IQR]: 51-70), and 29.70% of them resulted in a fatality. TAEs associated with PPIs were less likely to occur in elderly patients (65-75: OR = 0.91 [0.87-0.95], p < 0.001; >75: OR = 0.93 [0.89-0.98], p < 0.01). CONCLUSION: TAEs constitute a small but significant fraction of PPI-related AEs. This study highlights the need for cautious long-term use of PPIs and further research to understand the underlying mechanisms and risk factors. Clinicians should be aware of the potential tumor risks associated with prolonged PPI treatment. |
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| ジャーナル名 | Frontiers in pharmacology |
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| Pubmed追加日 | 2025/1/3 |
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| 投稿者 | Zhang, Ya-Jun; Duan, Dan-Dan; Tian, Qian-Yu; Wang, Cai-E; Wei, Shu-Xun |
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| 組織名 | Department of Pharmacy, The First Affiliated Hospital, and College of Clinical;Medicine of Henan University of Science and Technology, Luoyang, China.;Department of Pharmacy, Henan Provincial Corps Hospital of Chinese People's Armed;Police Force, Zhengzhou, China.;Department of Vascular Surgery, Eastern Hepatobiliary Surgery Hospital, Naval;Medical University/Second Military Medical University, Shanghai, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39749203/ |
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