| アブストラクト | The Gram-positive anaerobic bacterium Clostridioides difficile (CD) can produce intense exotoxins, contributing to nosocomial infections, and it is the most common cause of health-care-associated infectious diarrhea. Based on spontaneous Individual Case Safety Reports from EudraVigilance (EV), we conducted a descriptive analysis of Clostridioides difficile infection (CDI) cases that reported a spontaneous adverse reaction related to using ceftriaxone, colistimethate, ciprofloxacin, gentamicin, linezolid, meropenem, and piperacillin/tazobactam. Most ADR reports registered in EV that were related to CDI were associated with ceftriaxone (33%), ciprofloxacin (28%), and piperacillin/tazobactam (21%). Additionally, the disproportionality analysis performed showed that all studied antibiotics had a lower reporting probability when compared to clindamycin. A causal relationship between a drug and the occurrence of an adverse reaction cannot be established from EV data alone because the phenomena of underreporting, overreporting, and reporting bias may affect the results. Based on the analysis of the collected data, this study underlines the importance of surveillance and monitoring programs for the consumption of antibiotics. Furthermore, it is essential to use standardized laboratory tests to define CDI's nature accurately. To prevent this infection, specialists should collaborate and adhere strictly to antibiotic stewardship programs, hygiene practices, and isolation protocols. |
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| ジャーナル名 | Pharmaceuticals (Basel, Switzerland) |
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| Pubmed追加日 | 2023/11/25 |
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| 投稿者 | Vintila, Bogdan Ioan; Arseniu, Anca Maria; Morgovan, Claudiu; Butuca, Anca; Sava, Mihai; Birlutiu, Victoria; Rus, Luca Liviu; Ghibu, Steliana; Bereanu, Alina Simona; Roxana Codru, Ioana; Gligor, Felicia Gabriela |
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| 組織名 | Clinical Surgical Department, Faculty of Medicine, "Lucian Blaga" University of;Sibiu, 550169 Sibiu, Romania.;County Clinical Emergency Hospital, 550245 Sibiu, Romania.;Preclinical Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu,;550169 Sibiu, Romania.;Clinical Medical Department, Faculty of Medicine, "Lucian Blaga" University of;Department of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy,;"Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca,;Romania. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38004450/ |
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