| アブストラクト | Background: This study analyzed real-world data from 2004 to 2023 to evaluate the toxicity profile of tyrosine receptor kinase (TRK) inhibitor therapy. Method: A retrospective analysis of US FDA Adverse Event Reporting System data was conducted to identify adverse events in patients receiving TRK inhibitor therapy. Result: Entrectinib demonstrated toxicities primarily in the cardiovascular and nervous systems, followed by the renal and urinary system. Common adverse effects included dizziness, renal impairment, constipation, heart failure and taste disorders. Larotrectinib induced adverse events mainly in the hepatobiliary and nervous systems, with peripheral neuropathy, myalgia, renal impairment and increased alanine aminotransferase commonly reported. Conclusion: Careful monitoring and supportive care strategies are essential for managing adverse events associated with TRK inhibitor therapy. |
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| 組織名 | Department of Radiation Oncology, Nanfang Hospital, Southern Medical University,;Guangzhou, Guangdong, 510515, China.;Department of Neurology, The Third Affiliated Hospital of Southern Medical;University, 183 Zhongshan Avenue West, Tianhe District, Guangzhou, Guangdong,;510630, China.;The First Affiliated Hospital, Guangzhou University of Chinese Medicine,;Guangzhou, 510405, China. |
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