| アブストラクト | This study aims to investigate the prevalence and seriousness of drug-induced arrhythmia and to identify predictors associated with the seriousness of arrhythmia. Drug-induced arrhythmia cases reported to the Korean Adverse Event Reporting System Database (KAERS DB) from January 2012 to December 2021 were investigated. A disproportionality test was performed to detect the association of the etiologic medication classes and types, along with patient demographic information, with the seriousness of drug-induced arrhythmia. Logistic regression was performed to investigate the predictors that increase the risk of serious arrhythmia. The most common etiologic agent for drug-induced arrhythmia was sevoflurane, whereas serious arrhythmia was most prevalent with narcotics. Antibiotics (reporting odds ratio (ROR) 4.125; 95% CI 1.438-11.835), chemotherapy (ROR 6.994; 95% CI 2.239-21.542), and iodinated contrast media (ROR 8.273; 95% CI 3.062-22.352) had a strong association with the seriousness of drug-induced arrhythmia. Among numerous etiologic agents, ioversol (ROR 16.490; 95% CI 3.589-75.772) and lidocaine (ROR 12.347; 95% CI 2.996-50.884) were more likely to be reported with serious arrhythmia. Aging and comorbidity, primarily cancer, are the most contributing predictors associated with serious arrhythmia. Further studies on the clinical significance of patient-specific predictors for the increased risk of serious drug-induced arrhythmia are warranted to promote drug safety. |
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| ジャーナル名 | Pharmaceuticals (Basel, Switzerland) |
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| 投稿日 | 2023/11/25 |
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| 投稿者 | Go, Chaerin; Kim, Semi; Kim, Yujin; Sunwoo, Yongjun; Eom, Sae Hyun; Yun, Jiseong; Shin, Sooyoung; Choi, Yeo Jin |
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| 組織名 | Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447,;Republic of Korea.;Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul;02447, Republic of Korea.;Department of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499,;Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou;University, Suwon 16499, Republic of Korea.;Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University,;Seoul 02447, Republic of Korea. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38004477/ |
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