| アブストラクト | Chimeric antigen receptor (CAR) T-cell therapy has significantly advanced treatment outcomes for hematological malignancies; however, therapy-associated toxicities are often severe and sex-related differences in toxicity remain under-investigated. Here, we extract data from FDA Adverse Event Reporting System (FAERS) to evaluate sex-associated differences in CAR T-cell therapy toxicities. Among 7700 cases, females show higher reporting odds of cytokine release syndrome (CRS), with a reporting odds ratio (ROR) of 1.10 and a confidence interval (CI) of [1.00, 1.20], as well as leukemias (ROR = 1.34; CI [1.05, 1.70]). Elevated reporting odds in females are observed across multiple organ systems. Comparisons across cancer treatments indicate that sex-associated reporting patterns in CAR T-cell therapy cannot be attributed to baseline sex differences across cancer therapies. Stratified analyses further identify heterogeneity by cancer type and CAR T product. These results highlight distinct sex-associated toxicity patterns and may support incorporating sex into toxicity management. |
|---|
| 投稿者 | Liu, Yuan; Yang, Jingwen; Iqbal, Madiha; Uyanik, Mehmet; Luo, Mei; Yang, Liqi; Lou, Yanyan; Diao, Lixia; Oluwole, Olalekan O; Moslehi, Javid J; Johnson, Douglas B; Han, Leng |
|---|
| 組織名 | Department of Biostatistics and Health Data Science, Indiana University School of;Medicine, Indianapolis, IN, USA. yl218@iu.edu.;Brown Center for Immunotherapy, Indiana University School of Medicine,;Indianapolis, IN, USA. yl218@iu.edu.;Center for Computational Biology and Bioinformatics, Indiana University School of;Medicine, Indianapolis, IN, USA.;Indianapolis, IN, USA.;Division of Hematology-Oncology, Department of Medicine, Mayo Clinic,;Jacksonville, FL, USA.;Department of Bioinformatics and Computational Biology, The University of Texas;MD Anderson Cancer Center, Houston, TX, USA.;Division of Hematology and Oncology, Vanderbilt University Medical Center,;Nashville, TN, USA.;Section of Cardio-Oncology & Immunology; Cardiovascular Research Institute;(CVRI), University of California San Francisco, School of Medicine, San;Francisco, CA, USA.;Nashville, TN, USA. douglas.b.johnson@vumc.org.;Medicine, Indianapolis, IN, USA. lenghan@iu.edu.;Indianapolis, IN, USA. lenghan@iu.edu. |
|---|
