| アブストラクト | BACKGROUND: Abnormal results in commonly used primary care blood tests could be early markers of cancer in patients presenting with non-specific abdominal symptoms. METHODS: Using linked data from the UK Clinical Practice Research Datalink (CPRD) and national cancer registry we compared blood test use and abnormal results from the 24-months pre-diagnosis in 10,575 cancer patients (any site), and 52,875 matched-controls aged >/=30 presenting, with abdominal pain or bloating to primary care. RESULTS: Cancer patients had two-fold increased odds of having a blood test (odds ratio(OR):1.51-2.29) and 2-3-fold increased odds of having an abnormal blood test result (OR:2.42-3.30) in the year pre-diagnosis compared to controls. Raised inflammatory markers were the most common abnormality (74-79% of tested cases). Rates of blood test use and abnormal results progressively increased from 7 months pre-diagnosis in cancer patients, with relatively small corresponding increases in symptomatic controls. In cancer patients, the largest increases from baseline were raised platelets in males with abdominal pain (increased 33-fold), raised white blood cell count in males with abdominal bloating (increased 37-fold) and low albumin in females with either symptom (increased 22-41 fold). CONCLUSIONS: Common blood test abnormalities are early signals of cancer in some individuals with non-specific abdominal symptoms and could support expedited cancer diagnosis. |
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| ジャーナル名 | British journal of cancer |
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| Pubmed追加日 | 2025/1/12 |
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| 投稿者 | Rafiq, Meena; White, Becky; Barclay, Matthew; Abel, Gary; Renzi, Cristina; Lyratzopoulos, Georgios |
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| 組織名 | Epidemiology of Cancer Healthcare & Outcomes (ECHO) Group, Department of;Behavioural Science, Institute of Epidemiology and Health Care (IEHC), UCL,;London, UK. Meena.rafiq@ucl.ac.uk.;Department of General Practice and Primary Care, University of Melbourne,;Melbourne, Australia. Meena.rafiq@ucl.ac.uk.;London, UK.;University of Exeter Medical School, Exeter, UK.;Faculty of Medicine, University Vita-Salute San Raffaele, Milan, Italy. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39799273/ |
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