| アブストラクト | BACKGROUND: Recent drug safety concerns described fluoroquinolone (FQ)-induced peripheral nervous system reactions. The objective of this study was to characterize such reports from VigiBase. METHODS: The analysis included FQ-induced peripheral nervous system disorder adverse drug reaction (ADR) reports (up to July 2019). We looked into the disproportionality data in terms of proportional reporting ratio (PRR) and information component (IC) values, and descriptive analysis was performed for FQ-ADRs positive associations (ADRs, suspected FQs, potential risk factors, such as associated therapy and underlying disease). RESULTS: Disproportionality analysis revealed 4374 reports (3531 serious) with peripheral nervous system ADRs associated with at least three FQs (neuropathy peripheral, 5492; neuralgia, 481; polyneuropathy, 220; sensory loss, 99; peripheral sensorimotor neuropathy, 39). Among these, both time-to-onset and duration of reaction were mostly between 1-7 days and >/=30 days. Most of the ADRs were not recovered/resolved at the time of reporting. CONCLUSION: The results augment the existing data on FQ safety concerns, specifically their potential effect on the nervous system. |
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| ジャーナル名 | Pharmaceuticals (Basel, Switzerland) |
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| 投稿日 | 2022/2/27 |
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| 投稿者 | Huruba, Madalina; Farcas, Andreea; Leucuta, Daniel Corneliu; Bucsa, Camelia; Mogosan, Cristina |
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| 組織名 | Department of Pharmacology, Physiology and Physiopathology, Faculty of Pharmacy,;"Iuliu Hatieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca,;Romania.;Drug Information Research Center, "Iuliu Hatieganu" University of Medicine and;Pharmacy, 400349 Cluj-Napoca, Romania.;Department of Medical Informatics and Biostatistics, "Iuliu Hatieganu" University;of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35215256/ |
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