| アブストラクト | The study aim was to assess the abuse/misuse potential of second-generation antipsychotics (SGAPs) using VigiBase data. We extracted individual case safety reports of "Drug abuse, dependence and withdrawal" involving SGAPs up to June 2018. We assessed disproportionate reporting by calculating the information component, considering the lower end of the 95% credibility interval for the information component (IC025 ), and the proportional reporting ratio. We identified 1683 individual case safety reports recorded as "abuse, dependence and withdrawal" involving SGAPs, mainly quetiapine (n = 1089) and olanzapine (n = 209). The disproportional reporting indicators highlighted an association between "Drug abuse and dependence", and quetiapine, olanzapine and ziprasidone, as indicated by the IC025 (2.263, 0.259 and 1.051, respectively) and proportional reporting ratio values (3.929, 1.020 and 1.334, respectively). The abuse/misuse potential is confirmed for quetiapine and olanzapine and highlighted for the first time for ziprasidone. Physicians should consider these risks when prescribing these antipsychotics, especially to patients with history of drug abuse. |
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| ジャーナル名 | British journal of clinical pharmacology |
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| 投稿日 | 2022/5/29 |
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| 投稿者 | Roy, Sophie; Charreteur, Robin; Peries, Marianne; Kheloufi, Farid; Eiden, Celine; Nagot, Nicolas; Donnadieu-Rigole, Helene; Micallef, Joelle; Peyriere, Helene |
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| 組織名 | Addictovigilance Centre, Montpellier University Hospital, Montpellier, France.;Pathogenesis and Control of Chronic Infections, University of Montpellier,;INSERM, EFS, Montpellier, France.;Addictovigilance Centre, Department of Clinical Pharmacology and;Pharmacovigilance, University of Aix Marseille, INSERM UMR 1106 Institut de;Neurosciences des Systemes, Marseille, France.;Department of Addictology, Montpellier University Hospital, Montpellier, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35633029/ |
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