| アブストラクト | Tardive akathisia is a movement disorder characterized by internal restlessness with an uncontrollable urge to move, leading to repetitive movements. It is a common side effect of long-term treatment with dopamine D(2) receptor antagonists. In the present study, we analyzed the FDA Adverse Event Reporting System and IBM MarketScan Research Database to find a drug that can be used concomitantly with dopamine D(2) receptor antagonists and still reduce the risk of akathisia. Acetaminophen was determined to be the most effective akathisia-suppressing drug. In an experimental validation of the hypothesis, chronic treatment of rats with haloperidol caused akathisia symptoms, including increased stereotyped behavior and locomotor activity, and decreased immobility time. Acute treatment with acetaminophen significantly attenuated haloperidol-induced akathisia. In the ventral striata of these rats, acetaminophen prevented haloperidol-induced decrease in the number of c-Fos(+) preproenkephalin(+) neurons. These results suggest that acetaminophen is effective in suppressing tardive akathisia by activating indirect-pathway medium spiny neurons. |
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| 投稿日 | 2022/12/16 |
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| 投稿者 | Nagaoka, Koki; Nagayasu, Kazuki; Shirakawa, Hisashi; Kaneko, Shuji |
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| ジャーナル名 | Journal of pharmacological sciences |
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| 組織名 | Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences,;Kyoto University, Kyoto, Japan.;Kyoto University, Kyoto, Japan. Electronic address: skaneko@pharm.kyoto-u.ac.jp. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36522124/ |
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