| アブストラクト | AIMS: Evaluate glycated haemoglobin (HbA1c) and weight changes after 6 months of once-weekly (QW) injectable glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy in UK primary care. MATERIALS AND METHODS: Retrospective, non-interventional study, using the Clinical Practice Research Datalink Aurum primary care database, identified adults with type 2 diabetes (T2D) newly initiating a QW injectable GLP-1 RA between January 2020 and November 2021. Dual primary outcomes were proportion of patients with (1) HbA1c < 7% (<53 mmol/mol) and (2) weight loss categories (from 0% to 15+%) after 6 months of continuous GLP-1 RA therapy. RESULTS: The study cohort comprised 10 816 adults: mean +/- standard deviation age 58.8 +/- 11.4 years, baseline HbA1c 9.3% +/- 1.7% (78.1 +/- 18.6 mmol/mol) and body mass index 36.6 +/- 7.2 kg/m(2). Of 5236 patients with data, 32.8% achieved HbA1c < 7% after 6 months; this proportion was higher for time since T2D diagnosis <5 years (34.1%) versus longer disease duration: >/=5-<10 years (28.0%), >/=10-<15 years (18.7%) and >/=15 years (19.3%). Of 3963 patients with weight data, 22.0% did not lose weight; 34.0%, 27.0%, 11.4% and 5.6% achieved weight reductions of >0%-<5%, >/=5%-<10%, >/=10%-<15% and >/=15%, respectively. No major differences in weight loss were observed by diabetes duration. CONCLUSIONS: Two thirds of T2D patients receiving QW injectable GLP-1 RA for 6 months did not attain target HbA1c < 7%, and less than half and one-quarter of patients achieved >/=5% and >/=10% weight loss, respectively. Results suggest an unmet need for better clinical management of T2D in UK primary care. |
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| ジャーナル名 | Diabetes, obesity & metabolism |
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| Pubmed追加日 | 2025/1/22 |
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| 投稿者 | Gulati, Kunal; Wijndaele, Katrien; Webb, Joanne; von Arx, Lill-Brith; Seif, Monica; Jennison, Thomas; Geneidat, Antonia; Wild, Rosie; Wood, Robert; Khunti, Kamlesh |
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| 組織名 | Eli Lilly and Company Limited, Basingstoke, UK.;Eli Lilly and Company, Herlev, Denmark.;Adelphi Real World, Bollington, UK.;Diabetes Research Centre, University of Leicester, Leicester General Hospital,;Leicester, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39840515/ |
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