| アブストラクト | BACKGROUND: The Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets. METHODS: Two clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models. RESULTS: This Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853). CONCLUSION: We have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases. |
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| ジャーナル名 | BMC family practice |
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| 投稿日 | 2010/1/7 |
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| 投稿者 | Khan, Nada F; Perera, Rafael; Harper, Stephen; Rose, Peter W |
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| 組織名 | Department of Primary Health Care, University of Oxford, Old Road Campus, Oxford;OX3 7LF, UK. nada.khan@dphpc.ox.ac.uk |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/20051110/ |
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