| アブストラクト | Ensuring drug safety during pregnancy is critical due to the potential risks to both the mother and fetus. However, the exclusion of pregnant women from clinical trials complicates the assessment of adverse drug reactions (ADRs) in this population. This study aimed to develop and validate risk prediction models for pregnancy-related ADRs of drugs using advanced Machine Learning (ML) and Deep Learning (DL) techniques, leveraging real-world data from the FDA Adverse Event Reporting System. We explored three methods horizontal line Information Component, Reporting Odds Ratio, and 95% confidence interval of ROR horizontal line for classifying drugs into high-risk and low-risk categories. DL models, including Directed Message Passing Neural Networks (DMPNN), Graph Neural Networks, and Graph Convolutional Networks, were developed and compared to traditional ML models like Random Forest, Support Vector Machines, and XGBoost. Among these, the DMPNN model, which integrated molecular graph information and molecular descriptors, exhibited the highest predictive performance, particularly at the preferred term level. The model was validated against external data sets from SIDER and DailyMed, demonstrating strong generalizability. Additionally, the model was applied to assess the risk of 22 oral hypoglycemic drugs, and potential substructure alerts for pregnancy-related ADRs were identified. These findings suggest that the DMPNN model is a valuable tool for predicting ADRs in pregnant women, offering significant advancement in drug safety assessment and providing crucial insights for safer medication use during pregnancy. |
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| ジャーナル名 | Journal of chemical information and modeling |
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| Pubmed追加日 | 2024/11/29 |
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| 投稿者 | Peng, Jinfu; Fu, Li; Yang, Guoping; Cao, Dongshen |
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| 組織名 | Xiangya School of Pharmaceutical Sciences, Central South University, No. 172;Tongzipo Road, Changsha 410031, Hunan, China.;The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road,;Changsha 410031, Hunan, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39611337/ |
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