| アブストラクト | AIMS: This study aims to compare adverse drug reaction patterns of liraglutide, semaglutide and tirzepatide-glucagon-like peptide-1 receptor agonists (GLP-1 RAs) approved for anti-obesity medications-to evaluate their real-world safety. MATERIALS AND METHODS: This disproportionality analysis utilized a case-control design with VigiBase. The study focused on reports of adverse events associated with liraglutide, semaglutide and tirzepatide, selected based on warnings in the US Food and Drug Administration approval labels for each drug. Data were restructured using unique identifiers to differentiate individuals affected by adverse drug reactions. Multivariable logistic regression models estimated adjusted reporting odds ratios (aRORs) with 95% confidence intervals (CIs) to assess the association between various adverse events and GLP-1 RAs, adjusting for age, sex, region, reporter qualification, reporting year and concomitant medication. The information component (IC) was analysed, and signals of adverse drug reactions were considered significant only when both aROR and IC were statistically significant. RESULTS: Our analysis of targeted adverse drug reactions included 24 725 individuals using liraglutide, 21 454 using semaglutide and 11 538 using tirzepatide. Tirzepatide had fewer reports of adverse drug reactions compared with the other two drugs, and its pharmacovigilance association strength was the lowest. Semaglutide, however, was significantly associated with several unusual adverse events, including suicidal ideation and behaviour (IC, 1.53 [IC(025), 1.28]; aROR, 2.52 [95% CI, 2.18-2.93]), hair loss (IC, 0.78 [IC(025), 0.63]; aROR, 1.42 [95% CI, 1.30-1.55]) and vision loss (IC, 1.27 [IC(025), 1.13]; aROR, 1.80 [95% CI, 1.66-1.97]). CONCLUSIONS: Our findings emphasize the need for cautious prescribing and further research to ensure the safe use of these medications. |
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| ジャーナル名 | Diabetes, obesity & metabolism |
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| Pubmed追加日 | 2025/4/3 |
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| 投稿者 | Kim, Tae Hyeon; Lee, Kyeongmin; Park, Seoyoung; Oh, Jiyeon; Park, Jaeyu; Jo, Hyesu; Lee, Hayeon; Cho, Jaehyeong; Wen, Xuerong; Cho, Hanseul; Kim, Sunyoung; Yon, Dong Keon |
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| 組織名 | Center for Digital Health, Medical Science Research Institute, Kyung Hee;University Medical Center, Kyung Hee University College of Medicine, Seoul, South;Korea.;Department of Medicine, Kyung Hee University College of Medicine, Seoul, South;Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.;Department of Precision Medicine, Kyung Hee University College of Medicine,;Seoul, South Korea.;Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.;Department of Electronics and Information Convergence Engineering, Kyung Hee;University, Yongin, South Korea.;Department of Medicine, CHA University School of Medicine, Seongnam, South Korea.;Department of Pharmacy Practice and Clinical Research, College of Pharmacy,;University of Rhode Island, South Kingstown, Rhode Island, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston,;Massachusetts, USA.;Department of Family Medicine, Kyung Hee University Medical Center, Kyung Hee;University College of Medicine, Seoul, South Korea.;Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40176478/ |
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