| アブストラクト | Antimicrobial resistance is considered one of the major threats to public health and is an important factor that influences the patient's outcome in the intensive care unit. Pharmacovigilance can help raise awareness of potential drug resistance (DR) or ineffectiveness (DI) through adverse drug reaction reports that are submitted to different spontaneous reporting systems. Based on spontaneous Individual Case Safety Reports from EudraVigilance, we conducted a descriptive analysis of adverse drug reactions associated with meropenem, colistin, and linezolid, with a focus on DR and DI. Of the total adverse drug reactions (ADRs) reported for each analyzed antibiotic by 31 December 2022, between 2.38-8.42% and 4.15-10.14% of the reports were related to DR and DI, respectively. A disproportionality analysis was conducted to evaluate the frequency of reporting adverse drug reactions relevant to the DR and DI of the analyzed antibiotics compared to other antimicrobials. Based on the analysis of the collected data, this study underlines the importance of post-marketing drug safety monitoring in raising a warning signal regarding antimicrobial resistance, thereby potentially contributing to the reduction in antibiotic treatment failure in an intensive care setting. |
|---|
| ジャーナル名 | Antibiotics (Basel, Switzerland) |
|---|
| 投稿日 | 2023/5/27 |
|---|
| 投稿者 | Vintila, Bogdan Ioan; Arseniu, Anca Maria; Butuca, Anca; Sava, Mihai; Birlutiu, Victoria; Rus, Luca Liviu; Axente, Dan Damian; Morgovan, Claudiu; Gligor, Felicia Gabriela |
|---|
| 組織名 | Clinical Surgical Department, Faculty of Medicine, "Lucian Blaga" University of;Sibiu, 550169 Sibiu, Romania.;County Clinical Emergency Hospital, 550245 Sibiu, Romania.;Preclinical Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu,;550169 Sibiu, Romania.;Clinical Medical Department, Faculty of Medicine, "Lucian Blaga" University of;Fifth Surgical Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy,;400012 Cluj-Napoca, Romania. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37237821/ |
|---|
