| アブストラクト | BACKGROUND: Various adverse drug reactions (ADRs) are associated with proton pump inhibitors (PPIs). However, the effects of PPIs on the renal system are unclear so far. Thus, the main objective of the current study was to identify the possible signals of PPIs in the renal system. MATERIALS AND METHODS: Data mining algorithms such as proportional reporting ratio i.e. PRR (>/=2) with associated chi-squared value (>4), reporting odds ratio i.e. ROR (>/=2) with 95% confidence interval and case count (>/=3) were calculated to identify a possible signal. RESULTS: The calculated PRR and ROR have indicated a positive signal of PPIs with suspected chronic kidney disease, acute kidney injury, renal failure, renal injury, and end-stage renal disease. The subgroup analysis results have shown a greater number of cases in the age group (18-64 years) as compared to other age groups whereas the number of cases in the female was found to be more as compared to males. The sensitivity analysis results have also shown no significant impact of concomitantly administered drugs on the outcome. CONCLUSION: PPIs may be associated with various ADRs on the renal system. |
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| ジャーナル名 | Expert opinion on drug safety |
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| Pubmed追加日 | 2023/3/9 |
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| 投稿者 | Jain, Devanshi; Sharma, Gazal; Kumar, Anoop |
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| 組織名 | Department of Food Science and Technology, I.K. Gujral Punjab Technical;University Jalandhar, Kapurthala, India.;Department of Pharmacology and Clinical Research, Delhi Pharmaceutical Sciences;and Research University (DPSRU), New Delhi, India. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36888736/ |
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